Abstract:

[Abstract]   Objective   Toinvestigate the therapeutic effect of epigallocatechin gallate (EGCG) on the bladder neo-
plasm induced by N-methyl-N-nitrosourea (MNU) in Wistar rats.Methods   Seventy-two female rats were randomly divided into two groups, treatment group and control group. The rat model of bladder tumor was established by intravesical instillation of MNU (2mL/time, once every two weeks) inside bladder. Rats in treatment group were given EGCG (2mL/time, once/day), and control group were given the same volume of distilled water. Six rats were executed respectively at the3^rd, 5^th,7^th,9^th, 11^th and13^th  week, and the bladder histopathological changes were studied in two groups.Results  The untypical hyper-plasia was observed after5weeks. The bladder neoplasm was observed at the11^th week in control group. The bladder neo-plasm was not found in treatment group. There was a significantly lower   pathological score in treatment group than that of control group except for the first two weeks (P＜0.05).   Conclusion  EGCG is effective for treatment of the bladder neo-plasm induced by MNU.

Key words: urinary bladder neoplasms, tea, phenols, methylnitrosourea, models, animal, rats, Wistar