Abstract: Abstract Objective: To evaluate the safety and efficacy of Renal sympathetic denervation in resistant hypertension through analyzing patient’s blood pressure and renal function at six months. Methods: Follow up 11 cases at baseline, 3 days after the surgery, and six months. To analysis their clinical characteristics including risk factors, BP level, renal function and compared with the baseline. Result: Compared to baseline, the systolic and Diastolic blood pressure were significently lower at intraoperative than baseline, and the BP remain low level in 6 months after surgery, P＜0.001. Conclusions: Effects of renal sympathetic denervation on blood pressure is notable, and safety which proved by follow-up. The findings provide new insights into mechanisms of disease, and show a way for the growing worldwide population of resistant hypertension.

Key words: resistant hypertension, blood pressure, renal sympathetic denervation, therapy, eGFR