Abstract: Abstract: Objective To study the inhibitory effect on allergic asthma by adoptive transfer of 　　　CD8α-CD11c+ dendritic cells (DC) from Schistosoma japonicum-infected mice． Methods CD8α-CD11c+DC from S．japonicum-infected mice and naive were isolated and purified using microbeads respectively，. Twenty BALB/c mice were divided into four groups randomly．5×105 CD8α-CD11c+DCs from S．japonicum-infected mice were injected into the tail vein of each mouse in Group A，while 5×105 CD8α-CD11c+ DCs of na?ve were injected into the tail vein of each mouse in Group B. One hour after injection，mice in Group A、B and C were sensitized and challenged with ovalbumin to induce asthma．Four weeks later，all the mice were killed，and the left lungs were cut for histopathologica1 analysis．Results Compared with mice in Group B and C，pulmonary inflammation of mice in Group A diminished markedly．According to Underwood’s standard，average total scores of Group A，B，C and D were 7.67±2.34，l0.86±1.35，11.75±2.22and 4.5±1.73 respectively ( P< 0.05)． Conclusion CD8α-CD11c+ DC from S．japonicum infected mice can significantly inhibit allergic asthma．

Key words: Schistosoma japonicum, asthma, dendritic cells, adoptive transfer