Abstract: 【Abstract 】 Objective To reported a case of Ductal Adenocarcinoma of the Prostate g and the relevant literature was reviewed to investigate the diagnosis and treatment of this disease．evaluate the clinical and pathological characteristics treatment ,prognosis of ductal adenocarcinoma of the Prostate．Methods A 82-year-old male suffered from "frequency, urgency, 7 years, increased for 3 months" misdiagnosis of patients. His serum prostatic specific antigen(PSA)level was 2.38 ng?ml-1．transurethral prostatic resection，(TURP) was performed on him．Results The postoperative pathology showed a primary Ductal Adenocarcinoma．Gleason score was 8．With immunohistochemical staining，the tumor cells were positive for PSA ,PAP (prostatic acid phosphatase) ,CKAE and CKHW，but negative for androgen receptor．Postoperatively，the patient recovered fairishly but long-term effects need further follow-up．Conclusion Ductal Adenocarcinoma of the Prostate is a clinically rare subtype of prostate cancer and difficult to be found in early stage．The diagnosis depends on histopathologic and immunohistochemical studies．Radical prostatectomy is recommended for this disease．

Key words: prostate cancer, ductal adenocarcinoma, diagnosis, treatment.