Abstract: Abstract: Objectives To investigate islet βcell function in obese children with nonalcoholic fatty liver disease . Methods Three hundred and sixty-two obese children and one hundred and sixty-four normal children were enrolled in the study form June 2007 to April 2011. 170 of the obese children accompanied with NAFLD , 192 simple obese children without NAFLD. Triglycerides、cholesterol、fasting plasma glucose(FPG)、fasting insulin(FINS)、HbA1c were assayed in these children. Oral glucose tolerance test and insulin releasing test were performed in all obese children. The homeostasis model assessment – insulin resistance(HOMA-IR) ,insulin sensitivity index (QUICKI) and β-cell function index (HOMA-β) were calculated. Results FPG、FINS、HbA1c、HOMA-β and HOMA-IR in NAFL group were significantly higher than the other two groups(P<0.05); QUICKI in NAFLD group was significantly lower than the other two groups (P<0.05). The relevance ratio of abnormal glucose metabolism in NAFLD group was significantly higer than without NAFLD group(P<0.05). Obese children with nonalcoholic fatty liver disease existed impaired function of islet β-cell and glucolipid metabolism disorders. The impaired function of islet β-cell could be one of the pathogenesis for nonalcoholic fatty liver disease.

Key words: nonalcoholic fatty liver disease, obsess, children, islet βcell function, HbA1c