Abstract: 【Abstract】Purpose: Research how does hypothyroidism affect the metabolic indicators of pregnant women with gestational diabetes and the pregnancy outcome. Method: Choose 98 cases of pregnant women with gestational diabetes who made an examination and delivered between Jan. 2012 to Apr. 2012 in Tianjin Central Obstetrics and Gynecology Hospital. After the pregnant women of the third trimester came to hospital waiting for the parturition, fasting determine triglyceride(TC), cholesterol (TG), high density lipoprotein (HDL - C), low density lipoprotein (LDL - C), thyroid stimulating hormone (TSH), creatinine, urea nitrogen, uric acid, cystatin C, neonatal blood glucose testing blood glucose after childbirth. Grouped compare these cases according to TSH 0.3-3.0 MIU/ L. In one case, TSH<0.3 MIU/ L, and this is the hyperthyroidism group. In 62 cases, TSH 0.3-3.0 MIU/ L, and this is the normal contrast group. In 35 cases, TSH>3.0 MIU/ L, and this is the hypothyroidism group. Because there is only one case in the hyperthyroidism group, no statistical significance shows here. Just compare the clinical metabolic indicators and the pregnancy outcomes, including the incidence of gestational hypertension, placental abruption, premature birth, neonatal asphyxia, neonatal hypoglycemia, and neonatal birth weight, between the hypothyroidism group and the normal contrast group. Result: The averages of cholesterol, LDL, creatinine in the hypothyroidism group (TSH>3) are higher than which are in the normal contrast group (TSH 0.3-3), and the distinction has statistical significance. All the other metabolic indicators do not have statistical significance. Comparing the pregnancy outcomes of two groups, the incidences of gestational hypertension and premature birth in the hypothyroidism group are higher than which are in the normal contrast group, and the distinction has statistical significance. And comparing the incidences of premature rupture of membranes, placental abruption, postpartum hemorrhage, neonatal hypoglycemia, neonatal asphyxia between these two groups, the distinction do not have statistical significance, while the incidences of premature rupture of membranes, and postpartum hemorrhage are obviously higher in the hypothyroidism group. Conclusion: Hypothyroidism may aggravate the incidences of the metabolic disorders and adverse pregnancy outcomes of the pregnant women with GDM. It is recommended that pregnant women with GDM should screen the thyroid function, and make timely treatment to thyroid function abnormality.

Key words: Gestational diabetes, Hypothyroidism, Lipid metabolism, Pregnancy outcome