Abstract: Objective To evaluate the relationship between serum uric acid(SUA) levels and the severity of angiographic coronary artery disease in patients with CAD. Methods 474 consecutive patients underwent coronary angiography were selected according to inclusion criteria. Of them, 366 cases were diagnosed as CAD, 108 cases were Non-CAD. Patient with the lumen diameter less than 50% at least in one vessel according to coronary Angiography were diagnosed as CAD. The severity of angiographic CAD was assessed by:1.the number of diseased vessels;2. the CAG Gensini score. The SUA level of men>420μmol/L or women>357μmol/L were diagnosed as hyperuricemia (HUA). Results 1.The SUA levels of CAD patients (317.40 90.14 μmol/L) were higher than those in Non-CAD patients (267.59 73.97μmol/L) (P<0.05).The SUA levels of female CAD patients (293.87 79.88μmol/L) were higher than those in female Non-CAD patients (244.82 66.76 μmol/L)(P<0.05).The SUA levels of male CAD patients (324.96 92.06 μmol/L) were higher than those in male Non-CAD patients (298.28 72.74 μmol/L) (P>0.05).The percentage of HUA in CAD patients(21.9%)were significantly higher than those in Non-CAD patients(6.5%)(P<0.05).The percentage of HUA both in male and female CAD patients(men 19.9%;women 28.1% )were significantly higher than those in male and female Non-CAD patients (6.5%)(P<0.05) respectively. 2.A significantly higher percentage of CAD patients had SUA concentrations in the range corresponding to quartile 3(86.6%) and 4(88.1%) than quartile 1(65.3%) and 2(68.9%)(P<0.05).3.Logistic regression analysis showed that HUA was an independent risk factor of CAD (OR=2.639, 95%CI: 1.080～6.443,P=0.033). 4.Significant Spearman’s correlations were found between the SUA level and Gensini score (r =0.270,P < 0.01).The same results were found in different genders( men: r =0.171, P<0.01;women :r =0.298, P<0.01). Conclusion 1. HUA could be an independent risk factor of coronary artery disease. 2. SUA level was correlated with the severity of CAD in patients with angiographic CAD. The relationship trends to be a little stronger in women than that in men.

Key words: coronary artery disease, atherosclerosis, uric acid, hyperuricemia, coronary Angiography, Gensini score