Abstract: Objective To study the expression of adipocyte fatty-acid binding protein FABP4 in placental tissues and serum of normal and diabetic pregnant women. The relationship among body weight， substances and the insulin resistance index was discussed，.Methods The expression of FABP4 was detected in serum and placental tissues of diabetic pregnant women and normal ones，which are respectively grouping to normal and overwight according to body weight，with the application of enzyme-lingked immunosorbent assay（ELISA）. The fasting blood glucose，insulin levels， triglyeride and total cholesterol were determined separately. The indexes of insulin resistance， insulin sensitivity index， β-cell function， were calculated with homeostasis model （HOMA）. All relevant information was statistical analyzed. Restult 1. The body mass index before pregnancy，fasting blood glucose，fasting insulin，triglyeride，total cholesterol，insulin resistance index of GDM normal group were higher than NGT normal group （P＜0.05）. While the insulin sensitivity index， β cell function of GDM group were lower than NGT normal group. In GDM pregnant women，BMI change value，FBG，FINS，triglycerides，total cholesterol，HOMAIR in the overweight group were higher than normal group （P＜0.05），HOMAISI， HOMA-B% are lower than the normal group. 2.The differences among the four groups of the OD dates were significant（P＜0.05）. 3.Compared with the control normal group，positive cells of GDM normal is higher.The difference was statistically significant（Ｚ=-3.312，P=0.002）. The positive cells of GDM overweight is higher the GDM normal.The difference was statistically significant（Ｚ=-2.663，P=0.013）. Conclusion The adipocytokine- FABP4 may play an important role in the process of GDM.

Key words: gestational diabetes, insulin resistance, body weight, obesity, adipocyte fatty acid binding protein