Clinical efficacy of caragliflozin and empagliflozin in obese patients with type 2 diabetes mellitus

doi:10.11958/20252351

Abstract

Abstract:

Objective To analyze effects of caragliflozin and empagliflozin on inflammatory markers, glucose and lipid metabolism and miR-144 expression in obese patients with type 2 diabetes mellitus (T2DM). Methods A total of 148 obese T2DM patients admitted to our hospital from June 2021 to May 2024 were selected and divided into the caragliflozin group and the empagliflozin group by random number table method. The two groups were treated with canagliflozin and empagliflozin on the basis of conventional treatment for 6 months. The inflammatory indicators, glucose metabolism indicators, lipid metabolism indicators, microRNA-144 (miR-144) expression, body mass index (BMI), clinical efficacy and incidence of adverse reactions were compared between the two groups. Results After a total of 7 cases were excluded during the treatment period, there were 71 cases in the caragliflozin group and 70 cases in the empagliflozin group. After treatment, the levels of tumor necrosis factor-α, interleukin-6, C-reactive protein, fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h-PPG), glycosylated hemoglobin (HbA1c), triglyceride (TG), total cholesterol, low density lipoprotein cholesterol, BMI and miR-144 expression were lower than those before treatment in two groups of patients (P<0.05), and the levels of FBG, 2 h-PPG, HbA1c, TG and miR-144 expression were lower in the caragliflozin group than those of the empagliflozin group (P<0.05). After treatment, high density lipoprotein cholesterol was higher than that before treatment in the two groups (P<0.05), and that in the canagliflozin group was higher than the empagliflozin group (P<0.05). There were no significant differences in the clinical efficacy and incidence of adverse reactions between the two groups after treatment (P>0.05). Conclusion Both caragliflozin and empagliflozin have certain therapeutic efficacy and good safety for obese T2DM patients, and caragliflozin is more effective in improving glucose and lipid metabolism.

Key words: diabetes mellitus, type 2, obesity, microRNAs, canagliflozin, empagliflozin

CLC Number:

R587.1

Figures/Tables 7

References 22

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组别	n	性别		年龄/岁	病程/年	吸烟史	饮酒史	高脂血症	高血压史
组别	n	男	女	年龄/岁	病程/年	吸烟史	饮酒史	高脂血症	高血压史
卡格列净组	71	39（54.93）	32（45.07）	48.94±8.69	3.15±0.84	24（33.80）	18（25.35）	15（21.13）	20（28.17）
恩格列净组	70	37（52.86）	33（47.14）	48.29±8.91	3.26±0.76	19（27.14）	14（20.00）	11（15.71）	15（21.43）
χ²或t		0.061		0.450	0.769	0.738	0.576	0.687	0.858

组别	n	性别		年龄/岁	病程/年	吸烟史	饮酒史	高脂血症	高血压史
组别	n	男	女	年龄/岁	病程/年	吸烟史	饮酒史	高脂血症	高血压史
卡格列净组	71	39（54.93）	32（45.07）	48.94±8.69	3.15±0.84	24（33.80）	18（25.35）	15（21.13）	20（28.17）
恩格列净组	70	37（52.86）	33（47.14）	48.29±8.91	3.26±0.76	19（27.14）	14（20.00）	11（15.71）	15（21.43）
χ²或t		0.061		0.450	0.769	0.738	0.576	0.687	0.858

组别	n	TNF-α/（ng/L）			IL-6/（ng/L）			CRP/（mg/L）
组别	n	治疗前	治疗后	t	治疗前	治疗后	t	治疗前	治疗后	t
卡格列净组	71	23.68±3.17	16.23±2.30	16.472^＊＊	21.06±3.65	13.15±3.06	14.904^＊＊	3.76±0.97	2.03±0.87	10.845^＊＊
恩格列净组	70	24.12±3.39	16.82±2.67	14.275^＊＊	20.95±3.76	13.71±3.24	12.551^＊＊	3.68±0.84	2.18±0.91	10.145^＊＊
t		0.814	1.427		0.176	1.075		0.459	1.007

组别	n	TNF-α/（ng/L）			IL-6/（ng/L）			CRP/（mg/L）
组别	n	治疗前	治疗后	t	治疗前	治疗后	t	治疗前	治疗后	t
卡格列净组	71	23.68±3.17	16.23±2.30	16.472^＊＊	21.06±3.65	13.15±3.06	14.904^＊＊	3.76±0.97	2.03±0.87	10.845^＊＊
恩格列净组	70	24.12±3.39	16.82±2.67	14.275^＊＊	20.95±3.76	13.71±3.24	12.551^＊＊	3.68±0.84	2.18±0.91	10.145^＊＊
t		0.814	1.427		0.176	1.075		0.459	1.007

组别	n	FBG/（mmol/L）			2 h-PPG/（mmol/L）			HbA1c/%
组别	n	治疗前	治疗后	t	治疗前	治疗后	t	治疗前	治疗后	t
卡格列净组	71	10.56±1.23	6.16±0.91	25.430^＊＊	18.31±4.81	10.43±3.04	13.911^＊＊	9.12±0.75	6.96±0.67	17.322^＊＊
恩格列净组	70	10.41±1.17	6.53±0.97	20.460^＊＊	18.16±4.37	11.65±3.61	9.042^＊＊	9.06±0.84	7.23±0.78	12.366^＊＊
t		0.741	2.327^＊		0.211	2.169^＊		0.448	2.204^＊