Abstract: Objective To observe The effect of Pravastatin on the Expression of HSPB7 in acute myocardial infarction rats. Methods The 80 AMI rats were randomly divided into acute myocardial infarction group(AMI), and Pravastatin group(P), the 40 SD rat2 in sham operation group(SH),then subdivide each group into group 1h ,3h ,6h and 12h. SH was not ligated but threaded; AMI was created by ligation of the 1eft anterior descending coronary artery; Group P created by ligation of the 1eft anterior descending coronary artery with a Pravastatin of 0.5mg/（kg?d），the other groups were given the same amount normal saline via gavage. The myocardial tissue from left ventricular infarcted border zone was harvested at each time interval，while the corresponding myocardial tissue in sham-operated rats was harvested．HSPB7 mRNA and protein expressions were measured by RT-PCR and immunohistochemistry respectively．Results The expressions of HSPB7 mRNA and protein in the AMI groups and P groups were statistically significant( P＜0.001). All the above indexes exhibited an ascending tendency at 1h after AMI( P＜0.05)，reached peak value at 3h after AMI，and remaining detectable up to 12h after AMI，The P groups were still higher than those in the sham operation group. Conclusion HSPB7 could express in acute myocardial infarction rats in early times, and Pravastatin could promote the upregulation of the expressions of HSPB7 in myocardial infarcted border zone after AMI，which may be one of the mechanisms to protect myocardial after AMI

Key words: Acute myocardial infarction, HSPB7, Pravastatin