Abstract: Liu YiBing1,Ma Yun Fu2,Chen Jianshe3,Wang YinHui4 Abstract Objective: To evaluate the diagnostic value of TSSC1 in glioma patients and to the role influence on cell biology of glioma U87 cells. Methods: RT-PCR and Western blot were used to examine the expression of TSSC1 in samps, including 80 normal tissues and 80 primary tumors. MTT and transwell were used to analyze the ability of proliferation, migration, and invasion in TSSC1 siRNA-transfected U87 cells. Results: TSSC1 is down-regulated in glioma and related to higher grade. Furthermore, knockdown of TSSC1 expression results in increased proliferation and invasion in U87 cells in vitro. Conclusion: Our results may provide a strategy for blocking glioma and progression.

Key words: Glioma, TSSC1, Cell Biology