Abstract: Objective：To systematically assess the diagnostic value of f/t PSA and PSAD for prostate cancer in patients with tPSA level of 4-l0 ng/ml. Method：We retrieved the studies about f/t PSA and PSAD in the diagnosis of prostate cancer from the databases of Cochrane library，PubMed，Chinese Biomedical Literature Database，and so on. Quality of included trials was assessed according to QUADAS items. The software MetaDisc1.4 was used for data analysis. Result：A tota1 of 7 researches involving 1013 patients were included. Respectively, the pooled accuracy indicators of sensitivity, specificity of f/tPSA and PSAD were 0.78,0.54and 0.79,0.57.the area under curve of SROC curve of f/tPSA and PSAD were 0.7761 and 0.7821,Q index were 0.7153 and 0.7204．Conclusion：When the tPSA is 4-10ng/ml, f/t PSA and PSAD for prostate cancer diagnosis was no significant difference, both for the diagnosis of prostate cancer has important clinical value.

Key words: prostate cancer, prostate-specific antigen, diagnosis, meta analysis