Abstract: Objective To study changes of antibrain-antibody (ABAb)and interleukin-1β in rabbits with traumatic brain injury with drainage of cerebrospinal fluid therapy and to explore the protective effect of this therapy in rabbit—TBI—models established by lateral fluid percussion machine. Methods 32 rabbits were divided into four groups randomly (16 in control group, 16 in CSF drained group). Rabbits in control group were drained CSF and injected into cistern; rabbits in CSF drained group were drained CSF only. 2 groups rabbits were drained CSF 1ml everyday until a week and phlebotomized and tested with ELISA to observe the changes of IL-1βand ABAb at the time points 1 d, 3 d, 7d, 14d, 21d. Results Levels of IL-1βand ABAb in CSF drained group were lower than that in control group(P<0.05). The mortality rate and disability rate of CSF drained group were lower than those of control group, while the cure rate was the higher than that of control group. Conclusion Drainage of cerebrospinal fluid can help to decrease levels of antibrain-antibody and interleukin-1β. Drainage of cerebrospinal fluid therapy has protective effect on immunologic injury after traumatic brain injury.

Key words: Craniocerebral trauma, cerebrospinal fluid, immune, Antibrain antibody