XiaoYaoSan inhibits lung pre-metastatic niche formation through tumor immune microenvironment regulation

doi:10.11958/20220136

Abstract

CLC Number:

R73-37

Figures/Tables 10

References 22

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组别	MMP-9	S100A8	Fibronectin
模型组	1.00±0.00	1.00±0.00	1.00±0.00
逍遥散低剂量组	0.79±0.12^a	0.96±0.14	0.52±0.06^a
逍遥散中剂量组	0.63±0.06^ab	0.55±0.08^ab	0.46+0.05^ab
逍遥散高剂量组	0.26±0.04^abc	0.45±0.06^ab	0.26+0.06^abc
F	99.660^＊＊	53.200^＊＊	202.900^＊＊

组别	MMP-9	S100A8	Fibronectin
模型组	1.00±0.00	1.00±0.00	1.00±0.00
逍遥散低剂量组	0.79±0.12^a	0.96±0.14	0.52±0.06^a
逍遥散中剂量组	0.63±0.06^ab	0.55±0.08^ab	0.46+0.05^ab
逍遥散高剂量组	0.26±0.04^abc	0.45±0.06^ab	0.26+0.06^abc
F	99.660^＊＊	53.200^＊＊	202.900^＊＊

组别	F4/80⁺/iNOS⁺细胞（mm²）			CD206		ARG1
模型组	89.00±10.12			1.00±0.00		1.00±0.00
逍遥散低剂量组	102.33±12.57			0.65±0.08^a		0.84±0.07
逍遥散中剂量组	160.67±9.87^ab			0.26±0.06^ab		0.33±0.04^ab
逍遥散高剂量组	174.33±12.99^ab			0.18±0.03^ab		0.25±0.05^abc
F	67.637^＊＊			263.290^＊＊		305.852^＊＊
组别		PDL2	TGF-β（μg/L）		TNF-α（μg/L）
模型组		1.00±0.00	129.10±11.02		31.67±7.97
逍遥散低剂量组		0.76±0.07^a	113.00±7.86		42.33±7.80
逍遥散中剂量组		0.75±0.08^a	84.25±6.65^a		74.54±10.12^ab
逍遥散高剂量组		0.35±0.06^abc	77.67±10.55^ab		90.13±9.64^ab
F		97.404^＊＊	34.610^＊＊		46.580^＊＊

组别	F4/80⁺/iNOS⁺细胞（mm²）			CD206		ARG1
模型组	89.00±10.12			1.00±0.00		1.00±0.00
逍遥散低剂量组	102.33±12.57			0.65±0.08^a		0.84±0.07
逍遥散中剂量组	160.67±9.87^ab			0.26±0.06^ab		0.33±0.04^ab
逍遥散高剂量组	174.33±12.99^ab			0.18±0.03^ab		0.25±0.05^abc
F	67.637^＊＊			263.290^＊＊		305.852^＊＊
组别		PDL2	TGF-β（μg/L）		TNF-α（μg/L）
模型组		1.00±0.00	129.10±11.02		31.67±7.97
逍遥散低剂量组		0.76±0.07^a	113.00±7.86		42.33±7.80
逍遥散中剂量组		0.75±0.08^a	84.25±6.65^a		74.54±10.12^ab
逍遥散高剂量组		0.35±0.06^abc	77.67±10.55^ab		90.13±9.64^ab
F		97.404^＊＊	34.610^＊＊		46.580^＊＊

组别	p-STAT3	VEGF
模型组	1.00±0.00	1.00±0.00
逍遥散低剂量组	0.78±0.10^a	0.54±0.15^a
逍遥散中剂量组	0.41±0.09^ab	0.53±0.09^a
逍遥散高剂量组	0.39±0.12^ab	0.37±0.12^ab
F	54.260^＊＊	32.741^＊＊

XiaoYaoSan inhibits lung pre-metastatic niche formation through tumor immune microenvironment regulation

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