Research progress on the mechanism of the TGF-β signaling pathway in myelodysplastic syndrome

doi:10.11958/20231620

Abstract

Abstract:

Myelodysplastic syndrome (MDS) is a malignant clonal disease with high heterogeneity in cytogenetics and molecular genetics, and the risk of progression to acute myeloid leukemia (AML) is extremely high. Transforming growth factor-β (TGF-β) is closely related to the pathogenesis of MDS. It is a key executor of immune homeostasis and immune tolerance, and can inhibit the expansion and function of many components of immune system. TGF-β signaling pathway can regulate hematopoietic cells and immune cells in microenvironment, inhibit their normal biological functions, and thus accelerate the progression of MDS. This study reviews regulatory effects of TGF-β signaling pathway on MDS blood cells, T lymphocytes, natural killer cells and macrophages in recent years, and provides a new perspective for the pathogenesis and treatment of MDS.

Key words: myelodysplastic syndromes, transforming growth factor beta, signal transduction, immune cells, mechanism of action

CLC Number:

R552

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