Abstract: Abstract： Objective To investigate the correlation between helicobacter pylori (H.pylori) infection with gastric muco⁃ sa pathologic changes in chronic gastritis. Methods A total of 250 patients with chronic gastritis who came to Tianjin Union Medicine Center from November 2011 to March 2013 were collected in this study. Electronic gastroscope examina⁃ tions, pathology and Urea- 14C breath tests were performed in patients. There were 153 cases with chronic atrophic gastritis (CAG group), and 97 cases without chronic atrophic gastritis (non-CAG group). The positive rate of H.pylori was compared between two groups. At the same time the positive rate of H.pylori was compared between different parts of CAG patients. The positive rates of H.pylori were compared between different pathologic features of chronic gastritis (active degree, the de⁃ gree of inflammation, atrophy and intestinal classification). Results The positive rate of H.pylori was higher in CAG pa⁃ tients than that of non-CAG patients (70.6% vs 35%, χ2=30.552). The positive rate of H.pylori was higher in antral and cor⁃ pus atrophy of CAG group than that of antral atrophy (82.6% vs 65.4%, χ2=4.578). With the aggravating activity of gastritis, the inflammation, chronic gastritis, atrophy and intestinal classification, the positive rate of H.pylori was increased (χ2= 200.643, 206.715, 73.286, 218.432). Conclusion H.pylori infection is related with chronic gastritis, chronic atrophic gas⁃ tritis. And antral and corpus atrophy CAG is closely related with H.pylori infection.

Key words: gastritis, helicobacter pylori, infection, gastric mucosa