The change of phosphorylated MAP-2 in hippocampus/amygdala and the influence of
ginsenoside Rb1 on it in depressive rat model

doi:10.11958/20150266

Tianjin Med J ›› 2016, Vol. 44 ›› Issue (7): 846-848.doi: 10.11958/20150266

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The change of phosphorylated MAP-2 in hippocampus/amygdala and the influence of ginsenoside Rb1 on it in depressive rat model

LIU Jigang, YUAN Yang2 ZANG Yu, LIU Hao

1 Department of Stomatology, Zunhua Peolple’ s Hospital, Zunhua 064200; 2 Department of Neurology, Affiliated Hospital of North China University of Science and Technology

Received:2015-10-28 Revised:2016-03-24 Published:2016-07-15 Online:2016-07-15
Contact: LIU Hao E-mail:liuhao938@163.com

LIU Jigang, YUAN Yang2 ZANG Yu, LIU Hao. The change of phosphorylated MAP-2 in hippocampus/amygdala and the influence of ginsenoside Rb1 on it in depressive rat model[J]. Tianjin Med J, 2016, 44(7): 846-848.

Abstract

Abstract: Objectvie To observe the effcet of ginsenoside Rb1 on phosphorylation of microtubule-associated protein 2 (pMAP-2) in hippocampus and amygdala of depressive rats. Methods Thirty male Wistar rats were randomly divided into control group, model group and treatment group. The depression animal model was produced by giving the rats chronic unpredicted mild stress. The of pMAP-2 protein and mRNA were detected by western blot and real-time PCR respectively. Results The of pMAP-2 protein and mRNA of model group were lower than that of control group, while the index was higher after treatment with bupleurum liver-coursing powder (P<0.05). Conclusion Effect of ginsenoside Rb1 antidepressant may induced by affect the phosphorylation of MAP-2 in hippocampus.

Key words: ginsenoside Rb1, depression, hippocampus, amygdala, microtubule-associated protein

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The change of phosphorylated MAP-2 in hippocampus/amygdala and the influence of ginsenoside Rb1 on it in depressive rat model

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