Tianjin Medical Journal

Tianjin Medical Journal ›› 2017, Vol. 45 ›› Issue (1): 43-46.doi: 10.11958/20161228

• Clinical Study • Previous Articles     Next Articles

Clinical significance of serum procalcitotin in children with Kawasaki disease at acute stage #br# #br#

LIU Li1,2， WEI Wei 3， HU Jian2△ #br# #br#   

  1. 1 Graduate School of Tianjin Medical University, Tianjin 300070, China; 2 Department of Immunology, Tianjin Children’ s
    Hospital; 3 Department of Rheumatology and Immunology, Tianjin Medical University General Hospital

  • Received:2016-10-27 Revised:2016-12-05 Published:2017-01-15 Online:2017-01-15

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Abstract:

Abstract: Objective To investigate the changes and clinical significance of serum procalcitonin (PCT) level in
children with acute phase of Kawasaki disease (KD). Methods The serum PCT levels and their changes before and after
the treatment in 120 children with KD at acute phase were retrospectively analyzed. According to the results of ultrasonic
echocardiography, all children were divided into coronary artery damage (CAL) group and no coronary artery lesion (NCAL)
group. According to the presence of gastrointestinal symptoms, patients were divided into two groups (A: yes and B: no ).
According to the presence of abnormal liver function, patients were divided into two groups (C: yes and D: no). PCT levels
were compared between groups. Results The serum PCT levels were increased at acute phase in 56 (46.67% ) patients
before the treatment than those in normal children, which were decreased obviously after treatment (P＜0.05). There were 31
cases combined with CAL, the rising rate of PCT was 38.71%, which was no significant difference compared with that of 
NCAL group (49.44%, P＞0.05). There was no significant difference in serum PCT value between CAL group and NCAL
group (P＞0.05). The serum C-reactive protein level was significantly higher in CAL group than that of NCAL group. There
were 35 patients combined with gastrointestinal symptoms in 120 KD patients. There was no significant difference in the
rising rate of PCT between patients with gastrointestinal symptoms (62.86%) and patients without gastrointestinal symptoms
(40.00%, P＜0.05). There was no significant difference in serum PCT level between these two groups of patients. There were
42 cases with liver dyfunction in 120 KD patients, the PCT rising rate (52.38%) was no statistically significant difference
compared with that of patients with no liver dyfunction (43.59%, P＞0.05). And there was no significant difference in serum
PCT value between the two groups (P＞0.05). Conclusion PCT can reflect the acute phase of KD patients. The increased
PCT level may be related with the emergence of gastrointestinal symptoms, even though it cannot predict CAL and the
occurrence of liver damage.

Key words: mucocutaneous lymph node syndrome, calcitonin, coronary artery disease, gastrointestinal diseases, liver
diseases, Kawasaki disease, procalcitotin