天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (3): 271-273.doi: 10.11958/20161470

• 临床研究 • 上一篇    下一篇

老年急性心肌梗死合并 2 型糖尿病患者 PCSK9 水平与冠脉病变的相关性分析

夏雪， 张英武， 瞿德涛， 王丽△   

  1. 新疆石河子， 石河子大学医学院第一附属医院心内科 （邮编 832000）
  • 收稿日期:2016-12-06 修回日期:2017-01-30 出版日期:2017-03-15 发布日期:2017-03-21
  • 通讯作者: 王丽 E-mail:mcmwl@163.com

A correlation analysis of PCSK9 level and coronary artery disease in elderly patients with acute myocardial infarction complicated with type 2 diabetes mellitus

XIA Xue, ZHANG Ying-wu, QU De-tao, WANG Li△   

  1. Department of Cardiology, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi 832000, China
  • Received:2016-12-06 Revised:2017-01-30 Published:2017-03-15 Online:2017-03-21
  • Contact: WANG Li E-mail:mcmwl@163.com

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摘要： 摘要： 目的 探讨老年急性心肌梗死合并 2 型糖尿病患者血清枯草溶菌素转化酶 9 （PCSK9） 水平及其与冠脉病 变的相关性。方法 选取老年急性心肌梗死合并 2 型糖尿病患者 46 例为观察组， 同期住院的老年非糖尿病急性心肌梗死患者 34 例为阳性对照组， 慢性稳定性冠心病患者 33 例为阴性对照组。采用酶联免疫吸附试验 （ELISA） 检测血清 PCSK9 水平， 分析其与低密度脂蛋白胆固醇（LDL-C）、 高密度脂蛋白胆固醇（HDL-C）、 三酰甘油（TG）、 总胆固醇（TC）、 糖化血红蛋白（HbA1c）、 超敏 C 反应蛋白（Hs-CRP）和 Gensini 积分的相关性。结果 PCSK9、 HbA1c、 HsCRP 和 Gensini 积分在阴性对照组、 阳性对照组、 观察组均依次升高， 组间多重比较差异有统计学意义（P＜0.05）。观察组血清 PCSK9 水平与 Hs-CRP、 Gensini 积分呈正相关（P ＜0.05）， 与 HbA1c、 TG、 TC、 LDL-C、 HDL-C 无相关性（P＞0.05）。结论 PCSK9 与冠脉病变程度呈正相关， 可用于临床辅助判断老年急性心肌梗死合并 2 型糖尿病患者冠脉病变严重程度。

关键词: 冠状动脉疾病, 心肌梗死, 糖尿病, 2 型, 老年人, 前蛋白转化酶类, 枯草溶菌素转化酶 9

Abstract: Abstract: Objective To investigate the correlation between serum proprotein convertase subtilisin/kexin 9 (PCSK9)level and the severity of angiographic coronary artery disease (CAD) in elderly patients with acute myocardial infarction(AMI) complicated with type 2 diabetes mellitus (T2DM). Methods The patients over the same period were divided into three groups: the elderly patients with AMI and T2DM (observation group, n=46), the elderly non diabetic patients with AMI (positive control group, n=34) and patients with chronic stable coronary heart disease (negative control group, n=33). The serum PCSK9 level was detected by enzyme-linked immunosorbent (ELISA) in three groups. The correlation between serum PCSK9 level and low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol (TC), glycosylated hemoglobin (HbA1c), high sensitive C reactive protein (Hs-CRP) and Gensini score were analyzed. Results The levels of PCSK9, HbA1c, Hs-CRP and Gensini score showed a gradually increased tendency in negative control group, positive control group and observation group. Multiple comparison differences between groups were statistically significant (P < 0.05). The serum PCSK9 level was positively correlated with Hs-CRP and Gensini score in observation group (P < 0.05), and showed no correlation with HbA1c, TG, TC, LDL-C and HDL-C (P > 0.05). Conclusion The serum level of PCSK9 is positive correlated with the severity of CAD, which can be used to determine the severity of coronary artery lesions in elderly patients with AMI complicated with T2DM.

Key words: coronary artery disease, myocardial infarction, diabetes mellitus, type 2, aged, proprotein convertases, PCSK9