天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (10): 1033-1035.doi: 10.11958/20170642

• 临床研究 • 上一篇    下一篇

边缘区卒中后对学习记忆认知功能的影响

薛刘军，魏明，郑金龙   

  1. 南京医科大学附属淮安第一医院神经内科（邮编 223300）
  • 收稿日期:2017-06-05 修回日期:2017-08-21 出版日期:2017-10-15 发布日期:2017-10-13
  • 通讯作者: 郑金龙 E-mail:dillonzheng12@hotmail.com
  • 作者简介:薛刘军（1980），男，博士在读，主要从事认知功能障碍机制的研究
  • 基金资助:
    学习记忆的神经环路与分子基础研究;脑纹状体边缘区中学习记忆相关主要基因的表达;轻度认知障碍早期诊断脑功能磁共振动态研究

A study on memory disorder after marginal division of the striatum stroke

XUE Liu-jun, WEI Ming, ZHENG Jin-long   

  1. Department of Neurology, Huai’an First People’s Hospital, Nanjing Medical University, Jiangsu 223300, China
  • Received:2017-06-05 Revised:2017-08-21 Published:2017-10-15 Online:2017-10-13
  • Contact: Jin-long ZHENG E-mail:dillonzheng12@hotmail.com

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摘要： 目的 探讨纹状体边缘区卒中后对学习记忆认知功能的影响。方法 收集符合纳入标准的纹状体边缘 区卒中患者 21 例为卒中组，对照组为性别、年龄和教育程度与卒中组相匹配的健康志愿者 21 例；采用中国科学院 心理研究所编制的临床记忆量表行联想学习记忆测试。结果 卒中组得分明显低于对照组（17.71±5.59 vs. 24.80± 5.05）；卒中组左侧患者得分明显低于右侧患者（11.78±1.48 vs. 22.17±2.17），差异有统计学意义（P＜0.01）；但出血性 卒中和缺血性卒中得分差异无统计意义（16.50±6.59 vs. 18.46±5.01，P＞0.05）。结论 纹状体边缘区卒中后可引起患 者学习记忆认知功能减退，左侧边缘区卒中引起的记忆损害较右侧明显。

关键词: 卒中, 认知障碍, 记忆障碍, 纹状体边缘区

Abstract: Objective To explore the effects of marginal division of the striatum (MrD) stroke on associative learning and memory. Methods A total of 21 cases with marginal division of the striatum stroke were used as stroke group. The control group consisted of 21 healthy volunteers matched with the stroke group for sex, age and education. The clinical memory scale edited by Psychological research institute, Chinese academy of sciences was used to evaluate data of learning and memory. Results The score was significantly lower in stroke group compared with that of control group (17.71±5.59 vs. 24.80±5.05, P＜0.01). The score was significantly lower in patients with lesions on left than that in patients with lesions on right (11.78±1.48 vs. 22.17±2.17, P＜0.01). There was no significant difference in the score between hemorrhagic stroke group (16.50±6.59) and ischemic stroke group (18.46±5.01，P＞0.05). Conclusion Marginal division of the striatum stroke can cause the associative learning and memory disorder, which is more serious in patients with lesions on left than that in patients with lesions on right.

Key words: stroke, cognition disorders, memory disorders, marginal division of the striatum (MrD)