天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (4): 394-396.doi: 10.11958/20180012

• 临床研究 • 上一篇    下一篇

血清肝细胞生长因子在肺炎支原体肺炎 儿童中的检测意义

叶菁 1，2，刘长山 1△，王志华 2△   

  1. 作者单位：1天津医科大学第二医院儿科（邮编300211）；2天津市中西医结合医院南开医院儿科
  • 收稿日期:2018-01-02 修回日期:2018-02-28 出版日期:2018-04-15 发布日期:2018-04-15
  • 通讯作者: 刘长山 E-mail:chshliu@eyou.com
  • 基金资助:
    天津市卫生局科技项目

The significance of serum levels of HGF in children with mycoplasma pneumoniae pneumonia

YE Jing1，2，LIU Chang-shan1△, WANG Zhi-hua2△   

  1. 1 Department of Pediatrics, the Second Hospital Affiliated to Tianjin Medical University, Tianjin 300211, China; 2 Department of Pediatrics, Tianjin Nankai Hospital and Traditional Chinese and Western Medicine Hospital
  • Received:2018-01-02 Revised:2018-02-28 Published:2018-04-15 Online:2018-04-15
  • Contact: liu changshan E-mail:chshliu@eyou.com

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摘要： 摘要：目的 探讨血清肝细胞生长因子（HGF）在儿童肺炎支原体肺炎（MPP）中的作用及临床意义。方法 收集 2014年1月—2015年6月天津市中西医结合医院南开医院儿科住院的肺炎患儿107例，年龄3～14岁，分为MPP组 65例（重症MPP 27例，非重症MPP 38例），细菌性肺炎组42例，同时选择30例健康儿童作为对照组，采用酶联免疫吸 附试验（ELISA）方法检测血清中HGF水平。全自动生化分析仪检测重症MPP组和非重症MPP组患儿血清C反应蛋 白（CRP）、乳酸脱氢酶（LDH）的差异。结果 健康对照组、MPP 组及细菌性肺炎组 HGF 水平呈逐渐升高趋势 ［（4 174.3±247.6）、（6 507.1±1 895.9）及（7 128.7±1 990.2）ng/L］（P＜0.05），重症MPP组血清中HGF、CRP、LDH高于非 重症MPP组（P＜0.05）。结论 HGF参与了MPP的发生且与病情轻重有关，若结合患儿血清LDH及CRP均升高，提 示病情重，且耐药可能性大，应在给予大环内酯类药物的同时，给予糖皮质激素治疗。

关键词: 肝细胞生长因子, 支原体肺炎, 儿童, C反应蛋白, 乳酸脱氢酶

Abstract: Abstract：Objective To investigate the clinical significance of serum hepatocyte growth factor (HGF) in children with mycoplasma pneumoniae pneumonia (MPP). Methods A total of 107 children aged from 3-14 years old were enrolled in this study. Patients were consecutively hospitalized with pneumonia at the Department of Pediatrics, Tianjin Nankai Hospital and Traditional Chinese and Western Medicine Hospital from January 2014 to June 2015. The patients with pneumonia were divided into two groups: MPP group (n=65) and bacterial pneumonia group (n=42). Patients in MPP group was subdivided into two groups: severe MPP group (n=27) and non-severe MPP group (n=38). Thirty healthy children were used as control group in this study. The serum level of HGF was detected by ELISA. The serum levels of C reactive protein (CRP) and lactate dehydrogenase (LDH) were detected by an automated biochemistry analyzer in MPP patients. Results The serum levels of HGF were increased gradually in control group, MPP group and bacterial pneumonia group (ng/L: 4 174.3 ± 247.6, 6 507.1 ± 1 895.9 and 7 128.7 ± 1 990.2, P＜0.05). The serum levels of HGF, CRP and LDH were significantly higher in severe MPP group than those of non-severe MPP group (P＜0.05). Conclusion The serum level of HGF may play an important role in the pathogenesis of MPP in children, and which is connected to the severity of diseases. The higher levels of LDH and CRP suggest the severe MPP and macrolide-resistant. Glucocorticoid therapy should be given while the macrolide drugs are given.

Key words: hepatocyte growth factor, mycoplasma pneumoniae pneumonia, children, C-reactive protein, lactate dehydrogenase