天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (8): 946-950.doi: 10.11958/j.issn.0253-9896.2015.08.032

• 综述 • 上一篇    下一篇

类器官在前列腺癌相关研究中的作用探索

代亮，张志东，田垚，蒋宁，牛远杰   

  1. 天津医科大学第二医院；天津市泌尿外科基础医学重点实验室；天津市泌尿外科研究所
  • 收稿日期:2015-02-13 修回日期:2015-03-25 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 牛远杰 E-mail:tmudai@sina.com
  • 作者简介:代亮(1990)，男，硕士在读，主要从事前列腺癌相关方面研究

Role of organoid in prostate cancer research

DAI Liang，ZHANG Zhidong，TIAN Yao，JIANG Ning，NIU Yuanjie   

  1. Tianjin Institute of Urology；Tianjin Key Laboratory of Urology；The Second Hospital of Tianjin Medical University， Tianjin 300211, China
  • Received:2015-02-13 Revised:2015-03-25 Published:2015-08-15 Online:2015-08-15
  • Contact: NIU Yuanjie E-mail:tmudai@sina.com

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摘要： 类器官作为新一代临床前肿瘤模型，其建立对于揭示肿瘤生物学特性及探索对肿瘤患者有效的治疗方法具有重要意义。前列腺来源的类器官临床前肿瘤模型更是在前列腺肿瘤生物学特性研究和抗肿瘤药物筛选中发挥了巨大作用。当前普遍且成熟用于构建临床前前列腺肿瘤模型的方式有2 种：一种是前列腺肿瘤细胞株培养，另一种是人源性前列腺肿瘤组织异种移植。这2 种模型在前列腺癌基础研究与抗前列腺肿瘤药物筛选方面具有很高价值，但仍存在诸多无法回避的问题与劣势。最新研究构建的第三类临床前肿瘤模型——类器官或可解决当前2 种模型所存在的弊端。本文就类器官在前列腺癌相关研究中作用的研究进展作一综述。

关键词: 类器官, 前列腺肿瘤, 异种移植模型抗肿瘤试验, 综述, 临床前肿瘤模型, 前列腺肿瘤细胞系

Abstract: As a new model of pre-cancer, organoid is essential for the basic understanding of tumor characteristic and effective tumor treatment. Organoids derived from prostate play an especially important role in the research of fundamental oncology and anticancer drug screen against prostate cancer. Prostate cancer cell lines and xenografts derived directly from primary human tumors are widely used now as models to study prostate cancer and have proven very valuable. But there are some caveats and shortcomes of these two models that have to be accounted for. Here we outline organoid as a third preclini⁃ cal cancer model which may potentially overcome the shortcomes of cancer cell lines and PDTX. This article aims to summa⁃ rizee recent progress of the role of organoid in prostate cancer research.

Key words: organoid, prostatic neoplasms, X enograft model antitumor assays, review, reclinical model, prostate cancer cell lines