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铜绿假单胞菌联合滑石粉治疗恶性胸腔积液临床观察

黄崇标   

  1. 天津医科大学附属肿瘤医院
  • 收稿日期:2011-02-24 修回日期:2011-04-25 出版日期:2011-09-15 发布日期:2011-09-15
  • 通讯作者: 黄崇标

Clinical observation of PA-MSHA and talcum powder administration by thoracic cavity injection in the treatment of malignant pleural effusion

HUANG Chong biao   

  • Received:2011-02-24 Revised:2011-04-25 Published:2011-09-15 Online:2011-09-15
  • Contact: HUANG Chong biao

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摘要： 摘要 目的：观察铜绿假单胞菌联合滑石粉治疗恶性胸腔积液的疗效。方法：72例恶性胸腔积液患者经皮穿刺置管彻底引流胸腔积液，随机分成3组：治疗组28例为铜绿假单胞菌联合滑石粉治疗组、对照组A共24例为滑石粉对照组、对照组B共20例为铜绿假单胞菌对照组，经皮胸腔内注射，每周1次，连用1~3周。结果：治疗组总有效率高于对照组(?2=6.243，P=0.044)。不良反应方面，均未发生严重并发症，治疗组及对照组B患者接受干预后白细胞数较对照组A高（F=5.370, P=0.007）；对照组B发生胸痛比例较治疗组及对照组A低（P=0.011）； 治疗组和对照组中度以上发热比例无明显差异。结论：铜绿假单胞菌联合滑石粉治疗恶性胸腔积液是一种安全有效的治疗方法。

关键词: 恶性胸腔积液, 治疗, 胸膜固定术, 滑石粉, 铜绿假单胞菌

Abstract: Abstract Objective: To prospectively study the clinical efficacy of combined administration of pseudomonas aeruginosa-mannose sensitive hemagglutinin (PA-MSHA) and talcum powder in the treatment of malignant pleural effusion. Methods: 72 patients suffered from malignant pleural effusion were randomly divided into one observation group (28 cases) and two control groups (24 cases and 20 cases respectively). Patients in the observation group were given combined use of PA-MSHA and talcum powder, while patients in two control groups received PA-MSHA and talcum powder respectively. All the patients received thoracic close drainage by central vein catheterization set. Then the medicine was injected into thoracic cavity through the catheter. The weekly administration lasted 1~3 weeks depending on clinical efficacy. Results: The total effective rate of treatment group was higher than control groups (P<0.05). Compared with control groups, the treatment group showed no significant difference in serious side effects. Conclusion: Combined administration of PA-MSHA and talcum powder through thoracic drainage catheter proved to be a safe and effective method.

Key words: Malignant pleural effusion, Treatment, Pleurodesis, Talcum powder, PA-MSHA