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高血压患者红细胞分布宽度及直接胆红素与心房颤动的关系

缪帅1,刘彤2,李美佳1,吴英乐1,李广平2   

  1. 1. 天津医科大学第二附属医院
    2. 天津医科大学第二医院心脏科
  • 收稿日期:2012-07-26 修回日期:2013-01-17 出版日期:2013-06-15 发布日期:2013-06-15
  • 通讯作者: 李广平

Relationship between red cell distribution width，direct-bilirubin and paroxysmal atrial fibrillation in hypertensive patients

  • Received:2012-07-26 Revised:2013-01-17 Published:2013-06-15 Online:2013-06-15
  • Contact: Guangping LI

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摘要： 摘要 目的   探讨高血压患者红细胞分布宽度（RDW）及直接胆红素（D-BIL）与心房颤动（房颤）的关系及其临床意义。方法    连续入选我院心脏科住院的高血压合并阵发房颤患者40例作为房颤组，选择年龄、性别匹配的高血压不伴房颤者40例作为对照组，记录两组患者的年龄、性别、合并心血管疾病、实验室指标、心脏超声结果，应用多元Logistic回归分析房颤发生的危险因素。结果   房颤组患者RDW、D-BIL、尿酸及左房直径均高于对照组，左室射血分数低于对照组（P<0.05），Logistic多元回归分析显示D-BIL和左房直径为房颤发生的独立危险因素。结论   高血压患者阵发房颤的发生与D-BIL升高相关，其具体机制有待于进一步研究。

关键词: 心房颤动, 红细胞容量, 红细胞指数, 胆红素, 高血压

Abstract: Abstract   Objectives   To study the relationship between red cell distribution width（RDW）,direct-bilirubin（D-BIL）and paroxysmal atrial fibrillation(AF) in patients with hypertension. Method     Eighty patients, who were hospitalized in Second Hospital of Tianjin Medical University from October 2011 to April 2012,were enrolled in this study. The patients were divided into two groups: AF group and control group, according to the history of AF. The baseline clinical data were collected including age, sex, combined cardiovascular diseases, laboratory results and findings from echocardiography. The RDW and D-BIL level were compared and logistic regression model was established to identify the potential risk factors for paroxysmal AF. Results    The levels of RDW and D-BIL were significantly higher（P<0.05）in patients with AF than those in control group. Logistic regression analysis showed D-BIL and left atrial diameter（LAD）were the independent risk factors for the development of paroxysmal AF. Conclusion     The higher level of D-BIL may relate to the development of paroxysmal AF in hypertensive patients.

Key words: atrial fibrillation, Serum bilirubin, hypertension