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Apelin-13最新研究进展

符婉1,田绍文2,游咏1   

  1. 1. 南华大学附属第一医院神经内科
    2. 南华大学医学院生理教研室
  • 收稿日期:2014-04-16 修回日期:2014-06-11 出版日期:2014-11-15 发布日期:2014-11-15
  • 通讯作者: 符婉

Current Research Progress of Apelin-13

FU wan 1,TIAN Shao wen2,YOU Yong 1   

  1. 1. Department of Neurology, First Affiliated Hospital, University of South China
    2. Department of Physiology, Medical School, University of South China
  • Received:2014-04-16 Revised:2014-06-11 Published:2014-11-15 Online:2014-11-15
  • Contact: FU wan

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摘要： Apelin是由77个氨基酸构成的多肽，含有多种活性形式，其受体是血管紧张素样的孤儿G蛋白偶联受体——APJ。Apelin-13是含有13个氨基酸的短肽，具有较强的生物活性，是人体血液中常见的apelin亚型之一。Apelin-13在外周组织和中枢系统中都有表达，具有不同的生物功能和作用。已有研究显示apelin-13参与心血管系统、呼吸系统、神经系统、消化系统和内分泌系统的等病理生理过程，具有调控细胞增值、自噬、氧化应激和凋亡的作用，故apelin-13的研究也将促进疾病的预防和治疗。本文综述了apelin-13研究的最新进展，并展望了其发展前景。

关键词: Apelin-13, 心血管系统, 呼吸系统, 神经系统, 内分泌系统

Abstract:

[Abstract] Apelin is a polypeptide consisting of 77 amino acids. Apelin receptors are found to be the angiotensinlike G protein coupled receptor (APJ). Apelin/APJ system is widely distributed in the peripheral and central nervous system.
Apelin-13 is one of the subtypes of Apelin, which has strong biological activity. This study reviewed the new research progress of Apelin-13 on physiological and pathological processes involved in the cardiovascular system, respiratory system, nervous system, digestive system and endocrine system.

Key words: Apelin-13, cardiovascular system, respiratory system, central nervous system, endocrine system