• 短篇与病例报告 • 上一篇 下一篇
贾垂明,刘志强,梁欢,刘爱春
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贾垂明,刘志强,梁欢,刘爱春. 侵袭性NK细胞白血病一例报告[J]. .
摘要： 目的 提高对侵袭性NK细胞白血病的认识，探讨其治疗方法。方法 报告一例我院最近诊断的ANKL及其治疗过程，同时进行文献复习。结果 该病发病率低，进展快，含门冬酰胺酶及甲氨蝶呤化疗方案对其有效。结论 ANKL是一种罕见的独立的白血病，EB病毒感染与其有关，诊断时应结合临床特征，细胞形态学，免疫分型，基因重排等检查。治疗上以联合门冬酰胺酶及（或）甲氨蝶呤方案为主，序贯造血干细胞移植有可能延长患者生存期。
关键词: NK细胞, 白血病, 侵袭性, 诊断, 治疗
Abstract: Objective To improve the diagnosis and therapy of aggressive natural killer cell leukemia. Methods The characteristics of aggressive NK cell leukemia and its treatment were discussed with review of literatures. Results After combination chemotherapy which contained l-asparaginase and methotrexate,the patient would have a good result.Conclusion As aggressive NK cell leukemia is rare, its diagnose should include clinical mainfestation,cell morphology,immunophenotype,gene rearrangement.Treatment with joint asparaginase and (or) methotrexate scheme is given prior to hematopoietic stem cell transplantation ,which may prolong survival period.
Key words: Natural killer cell, leukemia, aggressive, diagnosis, therapy
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链接本文: https://www.tjyybjb.ac.cn/CN/
https://www.tjyybjb.ac.cn/CN/Y2014/V42/I5/469
