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血管生成负反馈调节因子Vasohibin家族研究进展

史刚刚   

  1. 天津医科大学大学第二医院
  • 收稿日期:2013-12-31 修回日期:2014-04-18 出版日期:2014-09-15 发布日期:2014-09-15
  • 通讯作者: 史刚刚

Recent advances on vasohibin family regulating angiogenesis

SHI Ganggang   

  1. Department of Colorectal Surgery, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • Received:2013-12-31 Revised:2014-04-18 Published:2014-09-15 Online:2014-09-15
  • Contact: SHI Ganggang

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摘要： 血管生成依赖于血管生成刺激因子和抑制因子之间的平衡。Vasohibin家族作为新近发现的血管生成调节因子，参与多种病理生理过程。其中Vasohibin-1是迄今为止发现的唯一以负反馈为作用机制调节血管生成的因子，抑制血管生成；而Vasohibin-2促进血管生成，表达于肿瘤细胞和单核细胞；研究还发现了一个小分子的Vasohibin结合蛋白，其存在于内皮细胞，可以Vasohibin-1和 Vasohibin-2结合，其与Vasohibin-1结合时，增强抗血管生成的活性，扮演分泌伴侣作用。本文就Vasohibin家族成员的结构特点、生物活性及在抑制病理性血管生成中的作用做一综述。

关键词: vasohibin, 血管生成, 新生血管化, 病理性, 内皮细胞, 综述

Abstract: Angiogenesis is regulated by the local balance between angiogenesis stimulators and inhibitors. Vasohibin family as a novel regulator of angiogenesis has impact on the process of various pathophysiology. Vasohibin-1 is the only one factor which has been found up to now that regulates angiogenesis by means of negative feedback as the mechanism of action. It is expressed in ECs to terminate angiogenesis. Subsequently one gene homologous to vasohibin-1 was found and designated as vasohibin-2. It is expressed in infiltrating MNCs or cancer cells to stimulate angiogenesis. Furthermore, one binding protein to vasohibin-1 and vasohibin-2 was discovered and renamed as small vasohibin-binding protein (SVBP). The analysis of the function of SVBP revealed that SVBP binds to vasohibin-1 within the cells, makes a heterodimer with vasohibin-1 and facilitates the secretion of vasohibin-1. This article reviews the construction features and biological activities of vasohibin family members and their effects of inhibiting pathology angiogenesis.

Key words: vasohibin, angiogenesis, neovascularization, pathologic, endothelial cells, review