天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (7): 722-725.doi: 10.11958/20170141

• 临床研究 • 上一篇    下一篇

c-Myc 在胃黏膜相关淋巴组织淋巴瘤患者预后评估中的意义

杨健，孙国锋，王翠英，刘诚聪，邢志远，陈瑞云，辛建军 ，田晨   

  1. 1 青岛市中心医院 （邮编 266042）； 2 天津医科大学肿瘤医院， 国家肿瘤临床医学研究中心， 天津市肿瘤防治重点实验室
  • 收稿日期:2017-02-03 修回日期:2017-06-19 出版日期:2017-07-15 发布日期:2017-08-08
  • 基金资助:
    国家自然科学基金资助项目 （81670104）

Significance of c-Myc in prognostic evaluation of gastric mucosa associated lymphoid tissue lymphoma

YANG Jian,SUN Guo-feng,WANG Cui-ying,LIU Cheng-cong,XING Zhi-yuan,CHEN Rui-yun,XIN Jian-jun,TIAN Chen   

  1. YANG Jian,SUN Guo-feng,WANG Cui-ying,LIU Cheng-cong,XING Zhi-yuan,CHEN Rui-yun,XIN Jian-jun,TIAN Chen
  • Received:2017-02-03 Revised:2017-06-19 Published:2017-07-15 Online:2017-08-08

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摘要： 目的 探讨 c-Myc 在胃黏膜相关淋巴组织 （MALT） 淋巴瘤中的表达及对预后的影响。方法 回顾性分析 2009 年—2015 年就诊于青岛市中心医院胃肠外科的 79 例胃 MALT 淋巴瘤患者的临床资料， 其中低危胃 MALT 淋巴瘤 38 例， 高危胃 MALT 淋巴瘤 20 例， 胃弥漫大 B 细胞淋巴瘤 （DLBCL） 21 例。Real-time PCR 分析淋巴瘤及其毗邻正常组织中 c-Myc 的表达水平， 结合临床资料评价其表达与患者预后的关系。结果 低危胃 MALT 淋巴瘤、 高危胃 MALT 淋巴瘤和胃 DLBCL 患者中 c-Myc mRNA 的阳性表达率分别为 15.7%（6/38）、 25%（5/20）和 28.5%（6/21）；且随着疾病的进展， 低危胃 MALT 淋巴瘤、 高危胃 MALT 淋巴瘤和胃 DLBCL 患者 c-Myc mRNA 的表达水平逐渐升高， 肿瘤大小及浸润深度也可影响 c-Myc 的表达。生存分析显示 c-Myc 表达阳性患者的总生存率及无复发生存率均低于 c-Myc 阴性患者 （P＜0.05）。结论 c-Myc 参与了胃 MALT 淋巴瘤的恶性转化， 可能在胃 MALT 淋巴瘤的发生发展中发挥作用。

关键词: 淋巴瘤, B 细胞, 边缘区, 胃肿瘤, 基因, myc, 预后, c-Myc

Abstract: Objective To investigate the expression of c-Myc in gastric mucosa associated lymphoid tissue (MALT)lymphoma and its implications on prognosis. Methods The clinical data of 79 patients hospitalized in our hospital from 2009 to 2015 were retrospectively analyzed. In these patients, 38 patients were low- grade MALT lymphoma, 20 patients were high-grade MALT lymphoma, 21 patients were diffused large B cell lymphoma (DLBCL). Real-time PCR was used to detect the levels of c-Myc expression in gastric MALT tissues and pair-matched adjacent normal tissues. The relationship between the expression of c- Myc and prognosis of patients was evaluated combing with the clinical data. Results Compared with the normal tissues, the expression levels of c-Myc protein were 15.7% (6/38), 25% (5/20) and 28.5% (6/21)in patients with low-grade MALT lymphoma, high-grade MALT lymphoma, and DLBCL. The relative expression levels of cMyc mRNA were gradually elevated in low-grade MALT lymphoma, high-grade MALT lymphoma and DLBCL. The tumor size and depth of invasion can influence the expression level of c-Myc. Survival analysis found that the overall survival rates and relapse-free survival rates were lower in patients with c-Myc positive expression than those of patients with negative expression (P＜0.05). Conclusion C-Myc plays a key role in the malignant transformation of gastric MALT lymphoma.

Key words: lymphoma, B-cell, marginal zone, stomach neoplasms, genes, myc, prognosis, c-Myc

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