天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (2): 207-212.doi: 10.11958/20181639

• 综述 • 上一篇    下一篇

肠道菌群在炎症相关肠癌中的研究进展

孔宪斌1 ， 王方园1 ， 彭莹莹1 ， 郭玉珠2 ， 孟静岩1△   

  1. 1天津中医药大学 （邮编301617）； 2天津市天津医院
  • 收稿日期:2018-10-30 修回日期:2018-12-06 出版日期:2019-02-15 发布日期:2019-02-15
  • 通讯作者: 孟静岩 E-mail:mengjy@163.com
  • 基金资助:
    天津市自然科学基金

Research progress of intestinal flora in colitis associated cancer

KONG Xian-bin1 , WANG Fang-yuan1 , PENG Ying-ying1 , GUO Yu-zhu2 , MENG Jing-yan1△   

  1. 1 Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; 2 Tianjin Hospital
  • Received:2018-10-30 Revised:2018-12-06 Published:2019-02-15 Online:2019-02-15

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摘要： 炎症相关肠癌 （CAC） 是世界医学难题， 肿瘤微环境是目前研究的热点， 肠道菌群失调与CAC的发病密切 相关， 肠道菌群失调加重结肠炎诱导CAC的发生。随着微生态学的发展， 肠道菌群在CAC研究中备受关注。本文概 述了CAC发生过程中肠道菌群与饮食、 炎症机制、 肠黏膜的关系以及在诊断、 治疗中相关研究， 重点讨论了肠道菌群 可能成为CAC作用机制的新靶点和相关应用前景。

关键词: 炎症, 肠肿瘤, 饮食习惯, 诊断, 治疗, 综述, 炎症相关肠癌

Abstract: Colitis associated cancer (CAC) is a worldwide medical problem. Tumor microenvironment is the hot spot of current research. Intestinal flora imbalance is closely related to the incidence of CAC and aggravates colitis-induced CAC. With the development of microecology, intestinal flora has received much attention in CAC research. This article outlines the relationship between intestinal flora and diet, inflammatory mechanisms and intestinal mucosa during CAC development, and the related research in diagnosis and treatment. It is mainly discussed that the intestinal flora may become a new target of CAC mechanism and its related application prospects.

Key words: inflammation, intestinal neoplasms, food habits, diagnosis, therapy, review, colitis associated cancer