天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (6): 636-639.doi: 10.11958/20181962

• 临床研究 • 上一篇    下一篇

110例卵巢功能早衰患者的危险因素分析

陈剑1,2 ， 仇姝2△   

  1. 1江苏大学医学院 （邮编212003）； 2扬州大学医学院附属医院扬州市妇幼保健院
  • 收稿日期:2018-12-07 修回日期:2019-04-15 出版日期:2019-06-15 发布日期:2019-06-15
  • 通讯作者: 仇殊 E-mail:chja099@163.com

Analysis of the risk factors of 110 cases of premature ovarian failure

CHEN Jian1,2 , QIU Shu2△   

  1. 1 Medical School of Jiangsu University, Zhenjiang 212003,China; 2 Yangzhou Maternal and Child Health-Care Center Affiliated to Medical School of Yangzhou University
  • Received:2018-12-07 Revised:2019-04-15 Published:2019-06-15 Online:2019-06-15

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摘要： 摘要:目的 调查分析引起妇女卵巢功能早衰 （POF） 的危险因素。方法 选取2015年1月—2017年12月本院诊治的POF患者110例为POF组， 同时选取110例健康体检女性为对照组。检测2组患者的促卵泡生成素 （FSH）、 促黄体生成素 （LH） 和雌二醇 （E2） 水平并进行比较； 同时对2组人员填写的 《女性卵巢功能早衰发病影响因素问卷表》进行统计分析。Logistic回归分析引起妇女POF的危险因素。结果 2组年龄及初潮年龄差异无统计学意义， POF组的FSH、 LH水平高于对照组、 E2水平低于对照组 （P＜0.05）； Logistic回归分析结果显示职业紧张、 睡眠不良、 吸烟或被动吸烟、 A型行为人格、 盆腔妇科手术史、 人流刮宫史是引起POF发生的危险因素 （P＜0.05， OR＞1）。结论 女性要重视上述引起POF的危险因素， 日常生活中减少这些方面的负面影响， 积极预防和减缓POF的发生发展。

关键词: 原发性卵巢功能不全, 危险因素, Logistic模型, 卵巢早衰

Abstract: Abstract: Objective To analyze the risk factors of premature ovarian failure (POF). Methods A total of 110 patients with POF who diagnosed and treated in our hospital from January 2015 to December 2017 were selected as POF group, and 110 healthy women were selected as control group. The levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) were detected and compared between the two groups. At the same time, the questionnaire about the influence factors of premature ovarian failure filled out by the two groups was collected and analyzed for statistical analysis. Logistic regression analysis of risk factors was used for POF in women. Results There were no statistically significant differences in terms of age and menarche age between the two groups. The hormone levels of FSH and LH were significantly higher in the POF group than those in the control group, and the level of E2 was significantly lower than that in the control group (P＜0.05). Logistic regression analysis showed that occupational stress, poor sleep, smoking or passive smoking, type A behavior pattern, history of pelvic gynecological surgery, history of abortion curettage were the risk factors of occurrence of POF (P＜0.05, OR＞1). Conclusion Women should pay attention to the above risk factors of POF, reduce the negative impact of these aspects in daily life to actively prevent and slow down the occurrence and development of POF.

Key words: primary ovarian insufficiency, risk factors, logistic models, premature ovarian failure