天津医药

天津医药 ›› 2022, Vol. 50 ›› Issue (5): 556-560.doi: 10.11958/20212314

• 综述 • 上一篇    

PI3K/AKT信号通路在心房颤动中的研究进展

张续腾1，刘芳2，陈军2，刘晓萌2，靳乐1，高红梅2△   

  1. 1山东中医药大学第二临床医学院（邮编250001）；2山东中医药大学第二附属医院心血管内科
  • 收稿日期:2021-10-13 修回日期:2021-11-22 出版日期:2022-05-15 发布日期:2022-07-04
  • 基金资助:
    国家自然科学基金项目（82104844）；山东省医药卫生科技发展计划项目（2019WS560）；山东省中医药科技发展计划项目（2019-0241）

Research progress of PI3K/AKT signaling pathway in atrial fibrillation

ZHANG Xuteng1, LIU Fang2, CHEN Jun2, LIU Xiaomeng2, JIN Le1, GAO Hongmei2△   

  1. 1 The Second Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan 250001, China; 
    2 Department of Cardiology, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine
  • Received:2021-10-13 Revised:2021-11-22 Published:2022-05-15 Online:2022-07-04

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摘要： 心房颤动（房颤）作为最常见的快速性心律失常，目前主要的治疗手段为抗凝、控制心室率、维持窦性心律。然而房颤的发生机制尚未阐明，上述治疗仍具有一定的局限性。磷脂酰肌醇3-激酶（PI3K）/蛋白激酶（AKT）信号转导通路是参与房颤发生发展的重要通路，其可以通过介导心房纤维化、炎症反应、氧化应激、神经内分泌功能调节参与房颤发生发展的病理生理过程。深入研究PI3K/AKT信号转导通路在房颤中的作用，可为房颤的预防、治疗及预后评估提供有价值的指导。

关键词: 心房颤动, 纤维化, 氧化性应激, 炎症, PI3K/AKT信号通路, 神经内分泌

Abstract: Atrial fibrillation (AF) is the most common tachyarrhythmia. At present, the main treatment methods of AF are anticoagulation, controlling ventricular rate and maintaining sinus rhythm. However, the mechanism of AF has not been elucidated, and the above treatment methods still have certain limitations. Phosphatidylin-3-kinase/protein kinase B (PI3K/AKT) signal transduction path is an important pathway involved in the occurrence and development of AF, which can be involved in the pathophysiological process related to AF through mediating atrial fibrosis, inflammation response, oxidative stress and neuroendocrine function regulation. In-depth study of the role of PI3K/AKT signal transduction pathway in AF can provide valuable guidance for the prevention, treatment and prognosis assessment of AF.

Key words: atrial fibrillation, fibrosis, oxidative stress, inflammation, PI3K/AKT signaling pathway, neuroendocrine

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