天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (9): 940-944.doi: 10.11958/20170302

• 临床研究 • 上一篇    下一篇

山楂消脂胶囊对湿热体质肥胖症患者的临床干预研究

赖锦兰，梁绮君，黄容，陈瑞珠，胡晨鸣，余寿益△   

  1. 广东省佛山市中医院健康管理中心（邮编 528000）
  • 收稿日期:2017-03-09 修回日期:2017-08-01 出版日期:2017-09-15 发布日期:2017-09-25
  • 通讯作者: 赖锦兰 E-mail:zhongljl@163.com
  • 基金资助:
    山楂消脂胶囊对肥胖症的临床干预研究及其机理探讨

Study of clinical intervention of Shanzha Xiaozhi capsule on obesity patients with dampness-heat constitution

LAI Jin-lan, LIANG Qi-jun, HUANG Rong, CHEN Rui-zhu, HU Chen-ming, YU Shou-yi△   

  • Received:2017-03-09 Revised:2017-08-01 Published:2017-09-15 Online:2017-09-25

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摘要： 摘要:目的 研究山楂消脂胶囊对湿热体质肥胖症患者的体质量、代谢指标、身体脂肪含量和分布的影响。方 法 将 60 例湿热体质肥胖症患者随机分成对照组和药物组，每组 30 例。对照组患者给予饮食和运动的生活方式 指导。药物组患者在生活方式指导的基础上，予山楂消脂胶囊口服，疗程为 12 周。比较 2 组患者治疗前后湿热积 分、体质量、腰围、臀围、血压、血糖、血脂、尿酸（UA）、胰岛素、血清肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1β、IL- 6、脂联素及脂多糖（LPS）水平的变化及身体脂肪含量和分布的变化。结果 （1）治疗后药物组湿热积分、舒张压均 较治疗前下降。与对照组相比，药物组湿热积分、臀围、血压均出现下降（均 P < 0.05）。（2）药物组治疗后三酰甘油 （TG）、UA、胰岛素、胰岛素抵抗指数（HOMA-IR）、LPS 及 IL-1β 水平均较对照组下降，但 2 组间空腹血糖（FBG）、餐 后 2 h 血糖（2 hPG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、TNF-α、IL-6、脂 联素水平差异无统计学意义。（3）与对照组相比，药物组内脏脂肪含量明显下降，但四肢及臀部脂肪无明显变化。结 论 山楂消脂胶囊可降低湿热体质肥胖症患者的体质量和内脏脂肪含量，减轻胰岛素抵抗，改善全身慢性炎症 状态。

关键词: 肥胖症, 胰岛素抵抗, 炎症, 减肥药, 山楂消脂胶囊, 湿热体质

Abstract: Abstract：Objective To investigate the effects of Shanzha Xiaozhi capsule on body weight, metabolic index, percentage and distribution of body fat in obese patients with dampness-heat constitution. Methods A total of 60 obesity patients with dampness-heat constitution were enrolled in this study and randomly categorized into the control group (n=30) and treatment group (n=30). Control group was given the diet and exercise regime, and treatment group was given Shanzha Xiaozhi capsule based on the same diet and exercise regime for 12 weeks. Scores of dampness- heat, body weight, waist circumference, hip circumference, blood pressure, blood glucose, serum lipid profile, urine acid (UA), fasting plasma insulin, serum levels of tumor necrosis factor- α (TNF-α), interleukin- 1β (IL-1β), IL-6, adiponectin, lipopolysaccharide (LPS), percentage and distribution of body fat were measured before and after treatment. Results (1) Data of scores of dampnessheat and diastolic blood pressure were significantly decreased after treatment in drug group. The above indexes and hip circumference were significantly decreased after the treatment in treatment group compared with those of control group (P < 0.05). (2) The triglyceride (TG), UA, insulin, HOMA-IR, LPS and IL-1β were significantly decreased after the treatment in treatment group than those of control group, while there were no significant differences in fast blood glucose (FBG), 2 h postprandial plasma glucose (2 hPG), total cholesterol (TC), low density lipoprotein cholesterol (LDL- C), high density lipoprotein cholesterol (HDL-C), TNF-α, IL-6 and adiponectin between two groups. (3) The percentage of visceral fat was significantly decreased in treatment group than that of control group. There were no significant differences in fat changes of limbs and buttocks between two groups. Conclusion Shanzha Xiaozhi capsule can decrease body weight and visceral fat content, reduce insulin resistance, and improve chronic inflammation state in obese patients with dampness- heat constitution.

Key words: obesity, insulin resistance, inflammation, anti-obesity agents, Shanzha Xiaozhi capsule, dampness-heat constitution