天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (4): 425-427.doi: 10.11958/20181755

• 临床研究 • 上一篇    下一篇

SIRT1、SIRT2和IL-37在子宫内膜异位症患者异位内膜组织的表达

张红霞 1，任春娥 2，王晓静 1，张勇 1，王桂丽 2△   

  1. 1潍坊医学院临床医学院（邮编 261053）；2潍坊医学院生殖医院
  • 收稿日期:2018-11-13 修回日期:2019-02-20 出版日期:2019-04-15 发布日期:2019-05-27
  • 通讯作者: 王桂丽 E-mail:guiliwang78@163.com
  • 作者简介:张红霞（1992），女，硕士在读，主要从事生殖方向研究

Expressions of SIRT1, SIRT2 and IL-37 in ectopic endometrium of patients with endometriosis

ZHANG Hong-xia1, REN Chun-e2, WANG Xiao-jing1, ZHANG Yong1, WANG Gui-li2△   

  1. 1 Graduate School of Weifang Medical University, Weifang 261053, China;2 Reproductive Hospital of Weifang Medical University
  • Received:2018-11-13 Revised:2019-02-20 Published:2019-04-15 Online:2019-05-27

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摘要： 目的 探讨 Sirtuin1（SIRT1）、Sirtuin2（SIRT2）及白细胞介素-37（IL-37）在正常子宫内膜组织及异位子宫 内膜组织表达的差异。方法 收集正常人子宫内膜组织及异位症患者异位内膜组织各 30例，采用免疫组织化学染 色检测 SIRT1、SIRT2及 IL-37蛋白的表达情况。结果 子宫内膜异位症患者异位内膜组织中 SIRT1、SIRT2、IL-37的 阳性表达率分别为 33.0%、20.0%、36.7%，均较正常子宫内膜组织（分别为 90.0%、86.7%、86.7%）显著降低（P＜0.05）。 不同月经周期对子宫内膜 SIRT1、SIRT2及 IL-37的表达无明显影响（P＞0.05）。结论 子宫内膜异位症患者异位内 膜中 SIRT1、SIRT2及 IL-37表达水平较低，提示子宫内膜异位症患者的异位内膜组织可能存在炎症反应。

关键词: 子宫内膜异位症, 炎症, SIRT1, SIRT2, IL-37, 免疫组织化学

Abstract: Objective To explore the differences of expressions of sirtuin1 (SIRT1), sirtuin2 (SIRT2) and interleukin - 37 (IL-37) in normal endometrium and ectopic endometrium. Methods Endometrial specimens were collected in 30 patients with endometriosis and 30 without endometriosis. Immunohistochemical staining was used to detect expressions of SIRT1, SIRT2 and IL-37 proteins. Results The positive expression rates of SIRT1, SIRT2 and IL-37 proteins in ectopic endometrium were 33.0%, 20.0% and 36.7% respectively, which were significantly lower than those of normal endometrial tissues (SIRT1 90%, SIRT2 86.7%, IL-37 86.7%, P＜0.05). There were no significant differences in expresssions of SIRT1, SIRT2 and IL-37 in endometrium between different menstrual cycles (P＞0.05). Conclusion The results suggest that the expression levels of SIRT1, SIRT2 and IL-37 in ectopic endometrium are low, suggesting that there may be inflammatory reaction in ectopic endometrium in patients with endometriosis.

Key words: endometriosis, inflammation, SIRT1, SIRT2, IL-37, immunohistochemistry