间充质干细胞在子宫内膜异位症中的研究进展

doi:10.11958/20231271

天津医药 ›› 2024, Vol. 52 ›› Issue (2): 215-219.doi: 10.11958/20231271

间充质干细胞在子宫内膜异位症中的研究进展

王鑫瑶¹(), 杨惠², 李冰冰¹^,^△()

1.济宁医学院临床医学院（邮编272000），2.中西医结合学院

收稿日期:2023-08-20 修回日期:2023-10-07 出版日期:2024-02-15 发布日期:2024-01-26
通讯作者: ^△ E-mail：lilucky0829@126.com
作者简介:王鑫瑶（2002），女，本科在读，主要从事子宫内膜异位症发病机制相关研究。E-mail：17705499092@139.com
基金资助:
国家自然科学基金资助项目(82104920);山东省自然科学基金青年项目(ZR2021QH129);山东省中医药科技项目(2021Q066);山东省中医药重点实验室(鲁卫涵[2022]331号)

Research progress of mesenchymal stem cells in endometriosis

WANG Xinyao¹(), YANG Hui², LI Bingbing¹^,^△()

1. Medical College, 2. College of Integrated Traditional Chinese and Western Medicine of Jining Medical University, Jining 272000, China

Received:2023-08-20 Revised:2023-10-07 Published:2024-02-15 Online:2024-01-26
Contact: ^△ E-mail: lilucky0829@126.com

王鑫瑶, 杨惠, 李冰冰. 间充质干细胞在子宫内膜异位症中的研究进展[J]. 天津医药, 2024, 52(2): 215-219.

WANG Xinyao, YANG Hui, LI Bingbing. Research progress of mesenchymal stem cells in endometriosis[J]. Tianjin Medical Journal, 2024, 52(2): 215-219.

摘要/Abstract

摘要：

子宫内膜异位症是一种常见的慢性妇科疾病，其发病机制至今尚未完全阐明。间充质干细胞是来源于中胚层的一类具有多向分化潜能的多能干细胞，可分化为多种组织和器官。子宫内膜间充质干细胞、经血源性间充质干细胞、脂肪间充质干细胞、骨髓间充质干细胞、脐带血间充质干细胞可从细胞增殖分化、异位迁移、血管生成、炎症反应及纤维化形成等方面参与子宫内膜异位症的发病，在疾病的进展中发挥着一定作用。间充质干细胞为阐明子宫内膜异位症的发病机制提供了新的思路，同时也或可成为治疗子宫内膜异位症的潜在方法。

关键词: 子宫内膜异位症, 间质干细胞, 细胞运动, 炎症, 发病机制

Abstract:

Endometriosis is a common chronic gynecological disease, and its pathogenesis has not been fully elucidated. Mesenchymal stem cells are a kind of pluripotent stem cells with multi-directional differentiation potential derived from mesoderm, which can differentiate into a variety of tissues and organs. Endometrial mesenchymal stem cells, menstrual blood-derived mesenchymal stem cells, adipose mesenchymal stem cells, bone marrow mesenchymal stem cells and umbilical cord blood mesenchymal stem cells can participate in the pathogenesis of endometriosis from cell proliferation and differentiation, ectopic migration, angiogenesis, inflammatory response and fibrosis formation, and play a certain role in progression of the disease. Mesenchymal stem cells provide new ideas for elucidating the pathogenesis of endometriosis, and may also become a potential method for the treatment of endometriosis.

Key words: endometriosis, mesenchymal stem cells, cell movement, inflammation, pathogenesis

中图分类号:

R711.71

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间充质干细胞在子宫内膜异位症中的研究进展

Research progress of mesenchymal stem cells in endometriosis

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