天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (4): 443-445.doi: 10.11958/j.issn.0253-9896.2015.04.030

• 综述 • 上一篇    下一篇

氧化三甲胺与动脉粥样硬化关系研究进展

王伟占1，2，田凤石2△   

  1. 1天津医科大学四中心临床学院（邮编300140）；2天津市第四中心医院
  • 收稿日期:2014-08-07 修回日期:2014-12-10 出版日期:2015-04-15 发布日期:2015-04-13
  • 通讯作者: 田凤石 E-mail:472399227@qq.com
  • 作者简介:王伟占（1987），女，硕士研究生在读，主要从事心血管内科研究

Review the connection between trimethylamine oxide and atherosclerosis

WANG Weizhan1,2, TIAN Fengshi2△   

  1. 1 The Fourth Center Clinical Institution of Tianjin Medical University, Tianjin 300140, China; 2 The Fourth Center Hospital of Tianjin
  • Received:2014-08-07 Revised:2014-12-10 Published:2015-04-15 Online:2015-04-13
  • Contact: TIAN Fengshi E-mail:472399227@qq.com

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摘要： 摘要：最新研究表明，肠道菌群与代谢综合征关系密切，与其重要的靶器官心血管系统关系尤为显著。肠道菌群对胆固醇、胆汁酸的代谢直接影响血中胆固醇的水平，同时胆固醇的水平又是动脉粥样硬化形成的关键环节。本文主要对肠道菌群依赖性代谢产物氧化三甲胺（trimetlylamine oxide,TMAO）与心血管疾病发病的根源动脉粥样硬化的关系进行综述。

关键词: 动脉粥样硬化, 代谢综合征X, 肠杆菌科, 心血管疾病, 胆固醇, 氧化三甲胺

Abstract: Abstract: Recent researches revealed that intestinal flora contribute to the development of metabolic syndrome, espe⁃ cially to the disorder of their targeted cardiovascular system. Blood cholesterol level is affected by the metabolism of intesti⁃ nal flora in cholesterol and bile acid. At the same time, the blood cholesterol level is the key player in development of athero⁃ sclerosis. This review mainly discussed the relationship between the intestinal flora dependent metabolite trimethylamine ox⁃ ide (Trimetlylamine oxide, TMAO) and atherosclerosis.

Key words: atherosclerosis, metabolic syndrome X, enterobacteriaceae, cardiovascular diseases, cholesterol, trimetlyl? amine oxide