Tianjin Med J ›› 2017, Vol. 45 ›› Issue (4): 428-431.doi: 10.11958/20170042

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Research progress of CX3CL1-CX3CR1 and the pathogenesis of sepsis

PENG Ding-wei1, QIN Yue-qiu2, LIAO Pin-hu2△   

  1. 1 The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China; 2 The Affiliated Hospital of Youjiang Medical College for Nationalities
  • Received:2017-01-10 Revised:2017-02-12 Published:2017-04-15 Online:2017-04-15
  • Contact: △审校者及通讯作者 E-mail:liaopinhu@163.com E-mail:liaopinhu@163.com

Abstract: Sepsis has poor prognosis, and its pathogenesis is not clear. Chemokine CX3CL1 (Fractalkine, FNK) has many functions such as chemotaxis, adhesion and mediate immune injury. CX3CR1 is the only receptor of CX3CL1 and participates in the development of sepsis. Here we review the structure, biological function and possible mechanism of CX3CL1 and CX3CR1 in the pathogenesis of sepsis.

Key words: sepsis, chemokine CX3CL1, receptors, CXCR, review