Abstract: Diabetes is an important independent risk factor for cerebrovascular diseases. A large number of clinical and experimental studies have confirmed that diabetes can aggravate cerebral ischemic injury, but the mechanism is not yet clear. Mitochondrial ATP-sensitive potassium channel (mitoKATP) is an important ion channel located in the mitochondrial inner membrane, playing very important roles in many physiological and pathological processes. In recent years, studies have showed that mitoKATP has a protective effect on cerebral ischemic neuronal injury, but its protective mechanism is abolished in diabetes. The relationship between mitoKATP and diabetes with cerebral ischemic injury has attracted more and more attention. In this article, the role of brain mitoKATP in diabetes with cerebral ischemic injury was reviewed.

Key words: diabetes mellitus, brain ischemia, KATP channels, mitochondria, review