Abstract: Abstract：Biliary atresia (BA) is a serious digestive system disease caused by the obliteration of intrahepatic and extrahepatic biliary system of infancy. Without prompt treatment, BA can cause biliary cirrhosis and ultimately develop to liver failure, leading child death. Bile duct epithelial cells are destroyed, leading to the formation of gradually narrowed bile duct lumen, and fiber cords are main pathological change of BA. The bile duct epithelial cells are not only the passive victims, but also the potential effect in biliary pathology. At present, with the deepening of the study of BA bile duct epithelial cells at home and abroad, some progress has been made in the destruction and repair of biliary epithelial cells. This article reviews the relationship between epithelial mesenchymal transformation (EMT), the changes in structure of bile duct, bile duct epithelial cell damage, bile duct proliferation and repairing, and hepatic fibrosis.

Key words: biliary atresia, cholangiocyte destruction, bile duct repair, epithelial mesenchymal transition, review