Abstract: Primary Sjogren’s syndrome (pSS) is a chronic systemic autoimmune disease mainly involving exocrine glands. Besides the involvement of salivary glands and lacrimal glands, it can also involve multiple external organs of glands, resulting in multiple system damage. At present, there is no effective systemic treatment for Sjogren’s syndrome at home and abroad. Most of the treatment for lesions outside glands are learned from the treatment for rheumatoid arthritis, systemic lupus erythematosus, or glucocorticoids or immunosuppressants based on clinical experience. Although biological agents have broad prospects in the treatment of Sjogren’s syndrome, there are still many disputes. This article will focus on the progress of the treatment for Sjogren’s syndrome of external organs of glands, and hope that it can be helpful to the clinical treatment of Sjogren syndrome.

Key words: Sjogren’s syndrome, autoimmune disease, external organs of the gland, review