Abstract: The cervus and cucumis polypeptide is widely used in clinical practice, mainly for arthritis, ankylosing spondylitis, various types of fractures, lumbocrural pain and other diseases. Reports of Kounis syndrome (anaphylaxis associated acute myocardial ischemia syndrome) caused by cervus and cucumis polypeptide are rare. In this paper, cervus and cucumis polypeptide was applied for osteoarthritis of the patient with no history of coronary heart disease. Kounis syndrome appeared after intravenous drip for one minute. The patient was cured and discharged after treatment with antianaphylaxis and acute myocardial ischemia. As a common clinical drug, the cervus and cucumis polypeptide should be alert to the possibility of Kounis syndrome if acute myocardial ischemia occurs.

Key words: anaphylaxis, myocardial ischemia, cervus and cucumis polypeptide, Kounis syndrome