Analysis of the relationship between IL-36γ level in umbilical cord blood and early infant eczema

doi:10.11958/20230643

Abstract

Abstract:

Objective To investigate the relationship between early infant eczema and cord blood interleukin (IL)-36γ level. Methods Fifty-nine full-term healthy newborns were selected as the study subjects. General information was collected including gender, birth weight, delivery method, gestational age, maternal age, physical fitness during pregnancy (diabetes, infection, hyperthyroidism and other complications), family history of allergies and intake times of seafood during pregnancy ≥3 times. The level of IL-36γ in umbilical cord blood after birth was detected by enzyme-linked immunosorbent assay. The presence and severity of eczema within 42 days were followed up. Multivariate Logistic regression was performed to analyze the influencing factors of early infant eczema, and receiver operating characteristics (ROC) were plotted to evaluate the diagnostic effectiveness. Results Among 59 infants, 40 had eczema, of which 35 were mild, 5 were moderate and 19 were eczema free. The proportion of seafood intake times ≥3 and the level of IL-36γ in umbilical cord blood were higher in the eczema group than those in the no-eczema group (P<0.05). There was no significant difference in IL-36γ level in cord blood between mild and moderate eczema patients. Multivariate Logistic regression analysis showed that the increased level of IL-36γ in umbilical cord blood and ≥3 intake times of seafood during pregnancy were risk factors for early infant eczema (P<0.05). ROC results showed that the AUC (95%CI) of umbilical cord blood IL-36γ was 0.743 (0.611-0.874), sensitivity was 87.6%, specificity was 57.9%, and truncation value was 103.823 ng/L. Conclusion The elevated level of IL-36γ in umbilical cord blood is an independent risk factor for early infant eczema, and early detection is valuable for predicting the occurrence of infantile eczema.

Key words: fetal blood, eczema, infant, anaphylaxis, interleukin 36γ

CLC Number:

R729

Figures/Tables 3

References 32

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组别		n	性别（男/女）		出生体质量/g		分娩方式（剖宫产/顺产）			胎龄（<39周/39周~40周/>40周）
无湿疹组		19	10/9		3 257.90±242.26		9/10			4/9/6
湿疹组		40	18/22		3 345.00±339.46		16/24			6/25/9
χ²或t			0.301		1.002		0.286			1.208
组别	母亲年龄/岁			喂养方式（母乳喂养/混合喂养）		家族过敏史（有/无）		孕期是否体健（是/否）	孕期海鲜类食物摄入次数≥3次（有/无）
无湿疹组	32.00±3.40			13/6		17/2		10/9	5/14
湿疹组	31.48±3.90			21/19		29/11		16/24	23/17
χ²或t	0.498			1.337		1.285		0.834	5.024^＊

组别		n	性别（男/女）		出生体质量/g		分娩方式（剖宫产/顺产）			胎龄（<39周/39周~40周/>40周）
无湿疹组		19	10/9		3 257.90±242.26		9/10			4/9/6
湿疹组		40	18/22		3 345.00±339.46		16/24			6/25/9
χ²或t			0.301		1.002		0.286			1.208
组别	母亲年龄/岁			喂养方式（母乳喂养/混合喂养）		家族过敏史（有/无）		孕期是否体健（是/否）	孕期海鲜类食物摄入次数≥3次（有/无）
无湿疹组	32.00±3.40			13/6		17/2		10/9	5/14
湿疹组	31.48±3.90			21/19		29/11		16/24	23/17
χ²或t	0.498			1.337		1.285		0.834	5.024^＊

变量	β	SE	Wald χ²	P	OR	OR 95%CI
母亲孕期海鲜类食物摄入次数≥3次	1.594	0.677	5.534	0.019	4.919	1.305~18.550
脐带血IL-36γ水平	0.002	0.001	4.430	0.035	1.002	1.000~1.004

变量	β	SE	Wald χ²	P	OR	OR 95%CI
母亲孕期海鲜类食物摄入次数≥3次	1.594	0.677	5.534	0.019	4.919	1.305~18.550
脐带血IL-36γ水平	0.002	0.001	4.430	0.035	1.002	1.000~1.004