Tianjin Medical Journal

Tianjin Med J ›› 2019, Vol. 47 ›› Issue (4): 431-435.doi: 10.11958/20182109

• Review • Previous Articles     Next Articles

Research progress of CREB in angiogenesis, anti-apoptosis and lung cancer

LIU Xiao, DUAN Yong, ZHANG Yan-liang   

  1. Yunnan Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Experimental Diagnosis, Kunming 650032, China
  • Received:2018-12-21 Revised:2019-01-15 Published:2019-04-15 Online:2019-05-27
  • Contact: Xiao Liu E-mail:18088446698@163.com
  • Supported by:
    Expression and Mechanism of CREB3L4 Gene in Xuanwei Lung Cancer in Yunnan Province;The role and molecular mechanism of CREB3L4 in the pathogenesis of lung cancer in Xuanwei, Yunnan

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Abstract: cAMP-response element binding protein (CREB) has been widely studied as a transcriptional factor in the field of long-term memory formation and the development and treatment of various malignant tumors. This review summarized the research progress of CREB gene in neovascularization, cell proliferation and anti-apoptosis, and the relationship between CREB geen and the carcinogenic process of nicotine and tumors (especially lung cancer) in order to provide references for future research of CREB family proteins.

Key words: cyclic AMP response element-binding protein, neovascularization, pathologic, apoptosis, nicotine, lung neoplasms, carcinoma