Abstract: Objective To investigate the effect of Guilong fistula protective coating on inflammatory factors and maturation of autologous arteriovenous fistula in patients with hemodialysis. Methods Ninety-two patients with chronic renal failure admitted to the dialysis department of Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine were selected as the research objects. All patients underwent autologousarterivenous fistula operation. The patients were divided into two groups by random number table. The observation group (n=46) was treated with Guilong fistula protective coating along the internal fistula vessels after operation, and the control group (n=46) was given routine internal fistula nursing. The differences of wall thickness, arterial resistance index, blood flow, blood vessel condition, serum inflammatory factors and fistula loss power were observed before and after treatment between the two groups. Results The vascular wall thickness and arterial resistance index were greater in the observation group than those of the control group at 8 weeks after operation (P＜0.01). The blood flow was greater in the observation group than that of the control group (P＜0.01), and the vascular elasticity was good, the proportion of weak vascular murmur was higher than those of the control group (P＜ 0.01). The serum levels of IL-6, tumor necrosis factor (TNF) -α, procalcitonin (PCT) and C-reactive protein (CRP) were significantly lower at 8 week in the observation group than those in the control group (P＜0.01). There was no significant difference in the power loss of autologousarteriovenous fistula at 1 year after operation between the two groups (P＞0.05). Conclusion Local external application of Guilong fistula protective coating can reduce the thickness and resistance of the arteriovenous fistula, increase blood flow, improve vascular condition, reduce the inflammatory reaction after operation, and promote the maturation of the internal fistula.

Key words: renal dialysis, arteriovenous fistula, ultrasonography, doppler, guilong fistula protective coating, autologousarteriovenous fistula, inflammatory factors