Abstract: Adipose mesenchymal stem cells (Adipose tissue-derived stem cells, ADSCs) are multidirectional differentiation potential cells from adipose tissue and are ideal sources of cell therapy. Genetically modified adipose mesenchymal stem cells not only have all the characteristics of ADSCs, but also can express some foreign genes efficiently and enhance their curative effect in the treatment of diseases, which brings a new opportunity for conventional clinical treatment of diseases which are difficult to cure. In this paper, the related progress in recent years is reviewed in order to provide reference for the application of gene modified ADSCs in clinical research.

Key words: adipose tissue-derived stem cells, gene modification, multiple differentiation, review