Abstract: Objective　To study the clinical effect of Danhong injection combined with conventional treatment in chronic kidney disease (CKD) with hypoxemia chronic obstructive pulmonary disease (COPD). Methods　Clinical data of CKD patients with hypoxemian COPD were retrospectively analyzed. There were 50 cases in the conventional treatment group and 50 cases in the Danhong injection group. The conventional treatment group was given the treatment of diuresis, detumescence, anti-inflammation, cough and phlegm, anti-spasmodic and anti-asthma. The Danhong injection group was given intravenous Danhong injection for 14 days on the basis of conventional treatment. Before and after the treatment, the change of indexes including arterial blood gas analysis, renal function and liver function were compared between the two groups. The total score of traditional Chinese medicine (TCM) syndromes, the effective rate of treatment, the improvement of hypoxemia and the safety of treatment were evaluated before and after treatment. Results　After treatment, compared with the conventional treatment group, p(O2) was increased in Danhong injection group, while p(CO2), blood β2, CYS-C and the total score of TCM syndromes were decreased in Danhong injection group (P＜0.05). In the Danhong injection group, blood urea nitrogen (BUN), β2-MG, CYS-C and the total score of TCM syndromes were decreased after treatment (P＜0.05). The therapeutic effect of Danhong injection group was superior than that of conventional treatment group (Z=2.268, P＜0.05). The improvement rate of hypoxemia was significantly higher in the Danhong injection group (56.00%) than that in the conventional treatment group (30.00%, χ2=4.889, P＜0.05). There were no significant differences in related indexed of liver function before and after treatment between the two groups (P＞0.05). Conclusion　Danhong injection can improve renal function, hypoxic environment and clinical symptoms in CKD patients with hypoxemia COPD.

Key words: kidney diseases, chronic disease, pulmonary disease, chronic obstructive, hypoxia, blood stasis, Danhong injection