Abstract: Objective To observe the influences of Qishen yiqi dropping pills on blood pressure, blood lipid, inflammatory factors, anginal symptoms and major adverse cardiovascular events in patients with hypertension complicated by coronary heart disease. Methods Data of 192 patients with hypertension complicated by coronary heart disease were retrospectively analyzed. Patients were randomly divided into two groups, 96 for each group. The control group were given standard treatment of coronary artery disease and hypertension. The experimental group were given Qishen yiqi dropping pills (0.5 g once, three times/d) combined with standard treatment of coronary artery disease and hypertension. Changes of systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low- density lipoprotein cholesterol (LDL-C), C-reactive protein (hs-CRP), interleukin 6 (IL-6), scores of symptom dimensions of Seattle angina pectoris scale (SAQ) including physical limitation, anginal stability, anginal frequency, treatment satisfaction and the incidence rate of major adverse cardiovascular events before and after treatment were compared between the two groups. Results Data of SBP, DBP, TC, LDL-C, hs-CRP and IL-6 were significantly decreased after treatment compared with that of before treatment (P＜0.01), and scores of physical limitation, anginal stability, anginal frequency and treatment satisfaction were significantly increased after treatment in the 2 groups (P＜0.05). After 1 year treatment, SBD, DBP, the levels of TC, LDL-C, hs-CRP and the incidence rate of major adverse cardiovascular events were significantly lower in the experimental group than those of the control group (P＜0.05). The scores of physical limitation, anginal stability, anginal frequency and treatment satisfaction were significantly higher in the experimental group than those of the control group (P＜0.01). Conclusion For patients with hypertension complicated by coronary heart disease, Qishen yiqi dropping pills can play a more effective role in lowering blood pressure, reducing levels of blood lipid and inflammation, and improving anginal symptoms and consequently reducing incidence rate of major adverse cardiovascular events, on the basis of standard Western medicine therapy.

Key words: coronary disease, hypertension, dyslipidemias, inflammation, Qishen yiqi dropping pills, major adverse cardiac events