Abstract: Objective　To observe the clinical effect of external diaphragm pacemaker (EDP) combined with respiratory trainer in patients with stable chronic obstructive pulmonary disease (COPD) complicated with type Ⅱ respiratory failure. Methods　A total of 82 patients with stable COPD complicated with type Ⅱ respiratory failure were enrolled and divided into the ventilator group (27 cases), the EDP group (26 cases) and the combined group (29 cases) according to the random number table method. Each group was given basic treatment according to the guidelines, abdominal top sandbag training and resistance cycling training. Breathing apparatus was added to the respirator group. The EDP group was given EDP treatment, and the combination group was given EDP combined with a breathing trainer for 10 weeks. Pulmonary function, blood gas analysis, exercise capacity and symptom scores were observed before and after treatment in each group. Results　FEV1%, FVC, FEV1/FVC%, p(O2) and 6MWT increased significantly, and p(CO2), mMRC and CAT decreased significantly before treatment in each group (P＜0.05). There were no significant differences in MMF%, SaO2, pH, HCO3- and BE between the groups (P＞0.05). After treatment, FEV1%, FVC, FEV1/FVC%, p(O2) and 6MWT significantly increased, and p(CO2), mMRC, CAT significantly decreased in the combined group than those of the ventilator group (P＜0.05). There were no significant differences in MMF%, SaO2, pH, HCO3- and BE between the groups (P＞0.05). Conclusion　EDP combined with breathing trainer can improve the pulmonary function index and hypoxia state of patients with stable COPD combined with type Ⅱ respiratory failure, improve exercise ability and relieve symptoms such as dyspnea, which is worthy of clinical application.

Key words: pulmonary disease, chronic obstructive, respiratory insufficiency, respiratory function tests, external diaphragm pacemaker, breathing training device