The clinical significance of serum levels of Gal-1 and CRH in patients with endometriosis

doi:10.11958/20220180

Abstract

Abstract:

Objective To investigate the serum levels and their clinical significance of galectin-1 (Gal-1) and corticotropin releasing hormone (CRH) in patients with endometriosis (EMS). Methods Ninety-three EMS patients were selected as the EMS group. At the same time, 90 healthy females of the same age for hospital examination were selected as the control group. The serum levels of Gal-1 and CRH were compared between the two groups. The correlation between the serum levels of Gal-1 and CRH and r-AFS stage was analyzed by Spearman correlation analysis. ROC curve was used to evaluate the diagnostic value of serum Gal-1 and CRH levels for infertility in EMS patients. Results The serum levels of Gal-1 and CRH were significantly higher in the EMS group than those in the control group (P<0.05). Binary Logistic regression analysis showed that higher levels of Gal-1 and CRH were independent risk factors affecting the occurrence of EMS (P<0.05). With the development of r-AFS stage, the serum levels of Gal-1 and CRH gradually increased (P<0.05). The serum levels of Gal-1 and CRH were positively correlated with r-AFS stage (P<0.05). Compared with EMS patients without infertility, serum Gal-1 and CRH levels were increased in EMS patients with infertility (P<0.05). ROC curve showed that the AUC value of Gal-1 combined with CRH was significantly higher [0.836 (0.753-0.919)] than that of single Gal-1 [0.767 (0.673-0.862)] or CRH [0.753 (0.652-0.854)], and its sensitivity and specificity were 82.22% and 79.17%, respectively. Conclusion The serum levels of Gal-1 and CRH are elevated in EMS patients. The combined detection of the two indicators has good diagnostic efficacy for infertility in EMS patients, which is beneficial to the early clinical targeted treatment.

Key words: endometriosis, galectin 1, corticotropin-releasing hormone, infertility

CLC Number:

R711.71

Figures/Tables 7

References 15

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组别	n		年龄（岁）	体质量指数（kg/m²）			月经量过多
对照组	90		34.18±8.71	20.89±1.11			32（35.56）
EMS组	93		34.02±7.26	21.14±1.06			41（44.09）
t或χ²			0.135	1.558			1.387
组别		痛经			流产	服用避孕药
对照组		24（26.67）			35（38.89）	52（57.78）
EMS组		53（56.99）			47（50.54）	61（65.59）
t或χ²		17.245^＊＊			2.509	1.182

组别	n		年龄（岁）	体质量指数（kg/m²）			月经量过多
对照组	90		34.18±8.71	20.89±1.11			32（35.56）
EMS组	93		34.02±7.26	21.14±1.06			41（44.09）
t或χ²			0.135	1.558			1.387
组别		痛经			流产	服用避孕药
对照组		24（26.67）			35（38.89）	52（57.78）
EMS组		53（56.99）			47（50.54）	61（65.59）
t或χ²		17.245^＊＊			2.509	1.182

组别	n	Gal-1（μg/L）	CRH（μg/L）	FSH（IU/L）	E2（ng/L）
对照组	90	5.17±1.23	4.03±1.08	2.59±0.75	45.16±14.03
EMS组	93	12.41±2.97	9.52±2.31	2.76±0.79	49.01±15.26
t		21.667^＊＊	20.700^＊＊	1.492	1.775

组别	n	Gal-1（μg/L）	CRH（μg/L）	FSH（IU/L）	E2（ng/L）
对照组	90	5.17±1.23	4.03±1.08	2.59±0.75	45.16±14.03
EMS组	93	12.41±2.97	9.52±2.31	2.76±0.79	49.01±15.26
t		21.667^＊＊	20.700^＊＊	1.492	1.775

因素	B	SE	Wald χ²	P	OR（95%CI）
痛经史	0.569	0.472	1.453	0.228	1.766（0.700~4.455）
Gal-1	0.625	0.298	4.399	0.036	1.868（1.042~3.350）
CRH	0.770	0.356	4.678	0.031	2.160（1.075~4.340）
常数项	-0.681	0.205	11.035	0.001	0.506