The effect of intrauterine infusion of danhong injection on pregnancy outcome of frozen-thawed embryo transfer in patients with thin endometrium

doi:10.11958/20220412

Abstract

Abstract:

Objective To investigate the effect of intrauterine infusion of danhong injection on the outcome of freeze-thawing embryo transfer (FET) in patients with thin endometrium caused by blood stagnation. Methods Sixty-six patients with infertility caused by thin endometrium and treated with FET were enrolled and randomly divided into the treatment group and the control group by random number table method, with 33 cases in each group. In the treatment group, follicular development was monitored from the day 8 to 10 of menstrual cycle, and danhong injection was used for intrauterine infusion every other day when the follicle diameter reached 14 mm to 18 mm. A total of 2-3 times of treatment were performed, while no intervention was given to the control group. After treatment, the endometrial thickness, endometrial blood flow type, live birth rate, positive rate of β-HCG, clinical pregnancy rate, ongoing pregnancy rate, early abortion rate, cycle cancellation rate and embryo implantation rate on human chorionic gonadotropin (HCG) injection day were compared between the two groups. Results The live birth rate, positive rate of β-HCG and persistent pregnancy rate were significantly better in the treatment group than those in the control group, and the endometrial thickness and endometrial blood flow type on ovulation day were significantly better in the treatment group than those in the control group (P<0.05). There were no significant differences in cycle cancellation rate, embryo implantation rate, early abortion rate and clinical pregnancy rate between the two groups (P>0.05). Conclusion Intrauterine infusion of danhong injection can improve pregnancy outcome in patients with thin endometrium with good safety.

Key words: perfusion, salvia miltiorrhiza, carthamus tinctorius, injectio, endometrium, thin endometrium, danhong injection, endometrial receptivity

CLC Number:

R271.9

Figures/Tables 3

Tab.1 Comparison of the general data between the two groups

组别	n	年龄（岁）	BMI（kg/m²）	不孕类型
组别	n	年龄（岁）	BMI（kg/m²）	原发不孕	继发不孕
对照组	33	32.64±2.06	22.65±1.37	10（30.3）	23（69.7）
治疗组	32	32.84±2.42	22.58±1.48	8（25.0）	24（75.0）
t或 $χ$ ²		0.372	0.199	0.228

Tab.1 Comparison of the general data between the two groups

组别	n	年龄（岁）	BMI（kg/m²）	不孕类型
组别	n	年龄（岁）	BMI（kg/m²）	原发不孕	继发不孕
对照组	33	32.64±2.06	22.65±1.37	10（30.3）	23（69.7）
治疗组	32	32.84±2.42	22.58±1.48	8（25.0）	24（75.0）
t或 $χ$ ²		0.372	0.199	0.228

Tab.2 Comparison of the intima-related data between the two groups

组别	n	内膜厚度		子宫内膜血流类型
组别	n	≤7 mm	>7 mm	Ⅰ型	Ⅱ型	Ⅲ型
对照组	33	18	15	18（54.5）	11（33.3）	4（12.1）
治疗组	32	7	25	5（15.6）	22（68.8）	5（15.6）
$χ$ ²		7.326^＊		11.113^＊

Tab.2 Comparison of the intima-related data between the two groups

组别	n	内膜厚度		子宫内膜血流类型
组别	n	≤7 mm	>7 mm	Ⅰ型	Ⅱ型	Ⅲ型
对照组	33	18	15	18（54.5）	11（33.3）	4（12.1）
治疗组	32	7	25	5（15.6）	22（68.8）	5（15.6）
$χ$ ²		7.326^＊		11.113^＊

Tab.3 Comparison of pregnancy outcomes between the two groups

组别	周期数	活产率	β-HCG 阳性率	临床妊娠率	持续妊娠率	早期流产率
对照组	33	3（9.1）	8（24.2）	6（18.2）	5（15.2）	2（6.1）
治疗组	32	11（34.4）	16（50.0）	12（37.5）	12（37.5）	1（3.1）
$χ$ ²		6.146^＊	4.628^＊	3.028	4.201^＊	0.318

Tab.3 Comparison of pregnancy outcomes between the two groups

组别	周期数	活产率	β-HCG 阳性率	临床妊娠率	持续妊娠率	早期流产率
对照组	33	3（9.1）	8（24.2）	6（18.2）	5（15.2）	2（6.1）
治疗组	32	11（34.4）	16（50.0）	12（37.5）	12（37.5）	1（3.1）
$χ$ ²		6.146^＊	4.628^＊	3.028	4.201^＊	0.318

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