Abstract: Objective　To investigate the changes and clinical significance of serum soluble lectin like oxidized low density lipoprotein receptor-1 (sLOX-1) and vertebral protein like protein-1 (VILIP-1) in neonates with hypoxic ischemic encephalopathy (HIE). Methods　A total of 146 neonates with HIE were selected as the HIE group. According to the clinical grading standard of HIE, the neonates were divided into the mild group (n=58), the moderate group (n=52) and the severe group (n=36). Another 50 normal neonates were selected as the control group. The serum levels of sLOX-1 and VILIP-1 were detected at 24 h (T1), 48 h (T2) and 72 h (T3) after birth in the HIE group, and the control group was detected at 24 h after birth (T1). Results　The 5 min Apgar score and NBNA score were significantly lower in the HIE group than those in the control group (P＜0.05). Over time, the serum levels of sLOX-1 and VILIP-1 were decreased in the HIE group (P＜0.05). Compared with the control group, the serum levels of VILIP-1 at each time point and the serum levels of sLOX-1 at the T1 and T2 time points were increased in the HIE group (P＜0.05). Over time, the serum levels of sLOX-1 and VILIP-1 were decreased in the mild, moderate and severe groups, and the serum levels of sLOX-1 and VILIP-1 were increased successively at each time point in the mild, moderate and severe groups (P＜0.05). Serum levels of sLOX-1 and VILIP-1 were negatively correlated with 5 min Apgar score and NBNA score in neonates with HIE (P＜0.05). Serum levels of sLOX-1(AUC=0.784, 95%CI: 0.702-0.869) and VILIP-1 (AUC=0.752, 95%CI: 0.655-0.847) showed high diagnostic values for HIE. The sensitivity [0.863 (126/146)] and the specificity [0.840 (42/50)] of the combined detection were significantly improved, and the diagnostic value was further improved. Conclusion　The expression levels of serum sLOX-1 and VILIP-1 increase in HIE, and their expression levels are related to the severity of the disease. Dynamic monitoring of serum levels of sLOX-1 and VILIP-1 is of great significance for the early diagnosis and disease assessment of HIE.

Key words: hypoxia-ischemia, brain, infant, newborn, diseases, early diagnosis, soluble lectin-like oxidized low density lipoprotein receptor 1, vertebrin-like protein 1